Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers

[Image: see text] IKKβ plays a central role in the canonical NF-kB pathway, which has been extensively characterized. The role of IKKα in the noncanonical NF-kB pathway, and indeed in the canonical pathway as a complex with IKKβ, is less well understood. One major reason for this is the absence of c...

Descripción completa

Detalles Bibliográficos
Autores principales: Anthony, Nahoum G., Baiget, Jessica, Berretta, Giacomo, Boyd, Marie, Breen, David, Edwards, Joanne, Gamble, Carly, Gray, Alexander I., Harvey, Alan L., Hatziieremia, Sophia, Ho, Ka Ho, Huggan, Judith K., Lang, Stuart, Llona-Minguez, Sabin, Luo, Jia Lin, McIntosh, Kathryn, Paul, Andrew, Plevin, Robin J., Robertson, Murray N., Scott, Rebecca, Suckling, Colin J., Sutcliffe, Oliver B., Young, Louise C., Mackay, Simon P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578373/
https://www.ncbi.nlm.nih.gov/pubmed/28737909
http://dx.doi.org/10.1021/acs.jmedchem.7b00484

Ejemplares similares

Ejemplares similares