Jagged1 expression by osteoblast-lineage cells regulates trabecular bone mass and periosteal expansion in mice

Loss-of-function mutations in the Notch ligand, Jagged1 (Jag1), result in multi-system developmental pathologies associated with Alagille syndrome (ALGS). ALGS patients present with skeletal manifestations including hemi-vertebrae, reduced bone mass, increased fracture incidence and poor bone healin...

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Detalles Bibliográficos
Autores principales: Youngstrom, D.W., Dishowitz, M.I., Bales, C.B., Carr, E., Mutyaba, P.L., Kozloff, K.M., Shitaye, H., Hankenson, K.D., Loomes, K.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578473/
https://www.ncbi.nlm.nih.gov/pubmed/27416809
http://dx.doi.org/10.1016/j.bone.2016.07.006

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