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Negative correlation of cortical thickness with the severity and duration of abdominal pain in Asian women with irritable bowel syndrome

BACKGROUND & AIMS: Irritable bowel syndrome (IBS) manifests as chronic abdominal pain. One pathophysiological theory states that the brain–gut axis is responsible for pain control in the intestine. Although several studies have discussed the structural changes in the brain of IBS patients, most...

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Autores principales: Chua, Chian Sem, Bai, Chyi-Huey, Shiao, Chen-Yu, Hsu, Chien-Yeh, Cheng, Chiao-Wen, Yang, Kuo-Ching, Chiu, Hung-Wen, Hsu, Jung-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578615/
https://www.ncbi.nlm.nih.gov/pubmed/28859146
http://dx.doi.org/10.1371/journal.pone.0183960
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author Chua, Chian Sem
Bai, Chyi-Huey
Shiao, Chen-Yu
Hsu, Chien-Yeh
Cheng, Chiao-Wen
Yang, Kuo-Ching
Chiu, Hung-Wen
Hsu, Jung-Lung
author_facet Chua, Chian Sem
Bai, Chyi-Huey
Shiao, Chen-Yu
Hsu, Chien-Yeh
Cheng, Chiao-Wen
Yang, Kuo-Ching
Chiu, Hung-Wen
Hsu, Jung-Lung
author_sort Chua, Chian Sem
collection PubMed
description BACKGROUND & AIMS: Irritable bowel syndrome (IBS) manifests as chronic abdominal pain. One pathophysiological theory states that the brain–gut axis is responsible for pain control in the intestine. Although several studies have discussed the structural changes in the brain of IBS patients, most of these studies have been conducted in Western populations. Different cultures and sexes experience different pain sensations and have different pain responses. Accordingly, we aimed to identify the specific changes in the cortical thickness of Asian women with IBS and to compare these data to those of non-Asian women with IBS. METHODS: Thirty Asian female IBS patients (IBS group) and 39 healthy individuals (control group) were included in this study. Brain structural magnetic resonance imaging was performed. We used FreeSurfer to analyze the differences in the cortical thickness and their correlations with patient characteristics. RESULTS: The left cuneus, left rostral middle frontal cortex, left supramarginal cortex, right caudal anterior cingulate cortex, and bilateral insula exhibited cortical thinning in the IBS group compared with those in the controls. Furthermore, the brain cortical thickness correlated negatively the severity as well as duration of abdominal pain. CONCLUSIONS: Some of our findings differ from those of Western studies. In our study, all of the significant brain regions in the IBS group exhibited cortical thinning compared with those in the controls. The differences in cortical thickness between the IBS patients and controls may provide useful information to facilitate regulating abdominal pain in IBS patients. These findings offer insights into the association of different cultures and sexes with differences in cortical thinning in patients with IBS.
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spelling pubmed-55786152017-09-15 Negative correlation of cortical thickness with the severity and duration of abdominal pain in Asian women with irritable bowel syndrome Chua, Chian Sem Bai, Chyi-Huey Shiao, Chen-Yu Hsu, Chien-Yeh Cheng, Chiao-Wen Yang, Kuo-Ching Chiu, Hung-Wen Hsu, Jung-Lung PLoS One Research Article BACKGROUND & AIMS: Irritable bowel syndrome (IBS) manifests as chronic abdominal pain. One pathophysiological theory states that the brain–gut axis is responsible for pain control in the intestine. Although several studies have discussed the structural changes in the brain of IBS patients, most of these studies have been conducted in Western populations. Different cultures and sexes experience different pain sensations and have different pain responses. Accordingly, we aimed to identify the specific changes in the cortical thickness of Asian women with IBS and to compare these data to those of non-Asian women with IBS. METHODS: Thirty Asian female IBS patients (IBS group) and 39 healthy individuals (control group) were included in this study. Brain structural magnetic resonance imaging was performed. We used FreeSurfer to analyze the differences in the cortical thickness and their correlations with patient characteristics. RESULTS: The left cuneus, left rostral middle frontal cortex, left supramarginal cortex, right caudal anterior cingulate cortex, and bilateral insula exhibited cortical thinning in the IBS group compared with those in the controls. Furthermore, the brain cortical thickness correlated negatively the severity as well as duration of abdominal pain. CONCLUSIONS: Some of our findings differ from those of Western studies. In our study, all of the significant brain regions in the IBS group exhibited cortical thinning compared with those in the controls. The differences in cortical thickness between the IBS patients and controls may provide useful information to facilitate regulating abdominal pain in IBS patients. These findings offer insights into the association of different cultures and sexes with differences in cortical thinning in patients with IBS. Public Library of Science 2017-08-31 /pmc/articles/PMC5578615/ /pubmed/28859146 http://dx.doi.org/10.1371/journal.pone.0183960 Text en © 2017 Chua et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chua, Chian Sem
Bai, Chyi-Huey
Shiao, Chen-Yu
Hsu, Chien-Yeh
Cheng, Chiao-Wen
Yang, Kuo-Ching
Chiu, Hung-Wen
Hsu, Jung-Lung
Negative correlation of cortical thickness with the severity and duration of abdominal pain in Asian women with irritable bowel syndrome
title Negative correlation of cortical thickness with the severity and duration of abdominal pain in Asian women with irritable bowel syndrome
title_full Negative correlation of cortical thickness with the severity and duration of abdominal pain in Asian women with irritable bowel syndrome
title_fullStr Negative correlation of cortical thickness with the severity and duration of abdominal pain in Asian women with irritable bowel syndrome
title_full_unstemmed Negative correlation of cortical thickness with the severity and duration of abdominal pain in Asian women with irritable bowel syndrome
title_short Negative correlation of cortical thickness with the severity and duration of abdominal pain in Asian women with irritable bowel syndrome
title_sort negative correlation of cortical thickness with the severity and duration of abdominal pain in asian women with irritable bowel syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578615/
https://www.ncbi.nlm.nih.gov/pubmed/28859146
http://dx.doi.org/10.1371/journal.pone.0183960
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