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Effect of general anesthesia on neonatal aEEG—A cohort study of patients with non-cardiac congenital anomalies
INTRODUCTION: The aim of the current study was to determine the effect of general anesthesia on neonatal brain activity using amplitude-integrated EEG (aEEG). METHODS: A prospective cohort study of neonates (January 2013-December 2015), who underwent major neonatal surgery for non-cardiac congenital...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578644/ https://www.ncbi.nlm.nih.gov/pubmed/28859124 http://dx.doi.org/10.1371/journal.pone.0183581 |
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author | Stolwijk, Lisanne J. Weeke, Lauren C. de Vries, Linda S. van Herwaarden, Maud Y. A. van der Zee, David C. van der Werff, Desiree B. M. Benders, Manon J. N. L. Toet, Mona Lemmers, Petra M. A. |
author_facet | Stolwijk, Lisanne J. Weeke, Lauren C. de Vries, Linda S. van Herwaarden, Maud Y. A. van der Zee, David C. van der Werff, Desiree B. M. Benders, Manon J. N. L. Toet, Mona Lemmers, Petra M. A. |
author_sort | Stolwijk, Lisanne J. |
collection | PubMed |
description | INTRODUCTION: The aim of the current study was to determine the effect of general anesthesia on neonatal brain activity using amplitude-integrated EEG (aEEG). METHODS: A prospective cohort study of neonates (January 2013-December 2015), who underwent major neonatal surgery for non-cardiac congenital anomalies. Anesthesia was administered at the discretion of the anesthetist. aEEG monitoring was started six hours preoperatively until 24 hours after surgery. Analysis of classes of aEEG background patterns, ranging from continuous normal voltage to flat trace in six classes, and quantitative EEG-measures, using spontaneous activity transients (SATs) and interSATintervals (ISI), was performed. RESULTS: In total, 111 neonates were included (36 preterm/75 full-term), age at time of surgery was (median (range) 2 (0–32) days. During anesthesia depression of brain activity was seen, with background patterns ranging from flat trace to discontinuous normal voltage. In most patients brain activity was two background pattern classes lower during anesthesia. After cessation of anesthesia, recovery to preoperative brain activity occurred within 24 hours in 86% of the preterm and 96% of the term infants. Gestational age and the dose of sevoflurane were significantly associated with SAT-rate (F(2,68) = 9.288, p < 0.001) and ISI- durations during surgery (F(3,71) = 12.96, p < 0.001). Background pattern and quantitative EEG-values were not associated with brain lesions (χ2(4) = 2.086, ns). CONCLUSION: aEEG shows a variable reduction of brain activity in response to anesthesia in neonates with noncardiac congenital anomalies, with fast recovery after cessation of anesthesia. This reduction is related to gestational age and the dose of sevoflurane. The aEEG offers the opportunity to monitor the depth of anesthesia in the neonate. |
format | Online Article Text |
id | pubmed-5578644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55786442017-09-15 Effect of general anesthesia on neonatal aEEG—A cohort study of patients with non-cardiac congenital anomalies Stolwijk, Lisanne J. Weeke, Lauren C. de Vries, Linda S. van Herwaarden, Maud Y. A. van der Zee, David C. van der Werff, Desiree B. M. Benders, Manon J. N. L. Toet, Mona Lemmers, Petra M. A. PLoS One Research Article INTRODUCTION: The aim of the current study was to determine the effect of general anesthesia on neonatal brain activity using amplitude-integrated EEG (aEEG). METHODS: A prospective cohort study of neonates (January 2013-December 2015), who underwent major neonatal surgery for non-cardiac congenital anomalies. Anesthesia was administered at the discretion of the anesthetist. aEEG monitoring was started six hours preoperatively until 24 hours after surgery. Analysis of classes of aEEG background patterns, ranging from continuous normal voltage to flat trace in six classes, and quantitative EEG-measures, using spontaneous activity transients (SATs) and interSATintervals (ISI), was performed. RESULTS: In total, 111 neonates were included (36 preterm/75 full-term), age at time of surgery was (median (range) 2 (0–32) days. During anesthesia depression of brain activity was seen, with background patterns ranging from flat trace to discontinuous normal voltage. In most patients brain activity was two background pattern classes lower during anesthesia. After cessation of anesthesia, recovery to preoperative brain activity occurred within 24 hours in 86% of the preterm and 96% of the term infants. Gestational age and the dose of sevoflurane were significantly associated with SAT-rate (F(2,68) = 9.288, p < 0.001) and ISI- durations during surgery (F(3,71) = 12.96, p < 0.001). Background pattern and quantitative EEG-values were not associated with brain lesions (χ2(4) = 2.086, ns). CONCLUSION: aEEG shows a variable reduction of brain activity in response to anesthesia in neonates with noncardiac congenital anomalies, with fast recovery after cessation of anesthesia. This reduction is related to gestational age and the dose of sevoflurane. The aEEG offers the opportunity to monitor the depth of anesthesia in the neonate. Public Library of Science 2017-08-31 /pmc/articles/PMC5578644/ /pubmed/28859124 http://dx.doi.org/10.1371/journal.pone.0183581 Text en © 2017 Stolwijk et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Stolwijk, Lisanne J. Weeke, Lauren C. de Vries, Linda S. van Herwaarden, Maud Y. A. van der Zee, David C. van der Werff, Desiree B. M. Benders, Manon J. N. L. Toet, Mona Lemmers, Petra M. A. Effect of general anesthesia on neonatal aEEG—A cohort study of patients with non-cardiac congenital anomalies |
title | Effect of general anesthesia on neonatal aEEG—A cohort study of patients with non-cardiac congenital anomalies |
title_full | Effect of general anesthesia on neonatal aEEG—A cohort study of patients with non-cardiac congenital anomalies |
title_fullStr | Effect of general anesthesia on neonatal aEEG—A cohort study of patients with non-cardiac congenital anomalies |
title_full_unstemmed | Effect of general anesthesia on neonatal aEEG—A cohort study of patients with non-cardiac congenital anomalies |
title_short | Effect of general anesthesia on neonatal aEEG—A cohort study of patients with non-cardiac congenital anomalies |
title_sort | effect of general anesthesia on neonatal aeeg—a cohort study of patients with non-cardiac congenital anomalies |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578644/ https://www.ncbi.nlm.nih.gov/pubmed/28859124 http://dx.doi.org/10.1371/journal.pone.0183581 |
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