Cargando…

Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients

PURPOSE: To determine whether multiple repeated administrations of gadolinium-based macrocyclic ionic MR contrast agent (MICA) are associated with intracranial gadolinium deposition and identify the predisposing factors for deposition in various clinical situations. MATERIALS AND METHODS: In this in...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Ji Ye, Park, Ji Eun, Kim, Ho Sung, Kim, Seon-Ok, Oh, Joo Young, Shim, Woo Hyun, Jung, Seung Chai, Choi, Choong Gon, Kim, Sang Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578663/
https://www.ncbi.nlm.nih.gov/pubmed/28859167
http://dx.doi.org/10.1371/journal.pone.0183916
_version_ 1783260576405782528
author Lee, Ji Ye
Park, Ji Eun
Kim, Ho Sung
Kim, Seon-Ok
Oh, Joo Young
Shim, Woo Hyun
Jung, Seung Chai
Choi, Choong Gon
Kim, Sang Joon
author_facet Lee, Ji Ye
Park, Ji Eun
Kim, Ho Sung
Kim, Seon-Ok
Oh, Joo Young
Shim, Woo Hyun
Jung, Seung Chai
Choi, Choong Gon
Kim, Sang Joon
author_sort Lee, Ji Ye
collection PubMed
description PURPOSE: To determine whether multiple repeated administrations of gadolinium-based macrocyclic ionic MR contrast agent (MICA) are associated with intracranial gadolinium deposition and identify the predisposing factors for deposition in various clinical situations. MATERIALS AND METHODS: In this institutional review board-approved retrospective study, 385 consecutive patients who underwent MICA-enhanced MR imaging were enrolled. The dentate nucleus-to-pons (DN/P) and globus pallidus-to-thalamus (GP/Th) signal intensity (SI) ratios on unenhanced T1-weighted images were recorded by 2 independent readers and averaged. The mean DN/P and GP/Th SI ratio difference between the last and the first examinations were tested using the one-sample t-test. Student’s t-test and stepwise regression analysis were used to identify the predisposing factors for deposition based on the number of administrations, time interval, hepatic and renal function, magnetic field strength, and chemo- or radiation therapy. RESULTS: The mean DN/P SI ratio difference was not different from zero (P = .697), even in patients with ≥20 administrations (n = 33). Only patients with abnormal renal function showed an increase in the mean DN/P SI ratio difference (P = .019). The mean DN/P SI ratio difference was not associated with any predisposing factors. However, the mean GP/Th SI ratio difference showed decrease (P < .001), which was associated with age (P = .007), number of administrations (P = .01) and number of radiation therapy sessions (P = .022) on multivariate analysis. CONCLUSION: Multiple repeated administrations of MICA were not associated with increased T1 signal intensity in deep brain nuclei suggestive of Gd deposition in patients with normal renal function.
format Online
Article
Text
id pubmed-5578663
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-55786632017-09-15 Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients Lee, Ji Ye Park, Ji Eun Kim, Ho Sung Kim, Seon-Ok Oh, Joo Young Shim, Woo Hyun Jung, Seung Chai Choi, Choong Gon Kim, Sang Joon PLoS One Research Article PURPOSE: To determine whether multiple repeated administrations of gadolinium-based macrocyclic ionic MR contrast agent (MICA) are associated with intracranial gadolinium deposition and identify the predisposing factors for deposition in various clinical situations. MATERIALS AND METHODS: In this institutional review board-approved retrospective study, 385 consecutive patients who underwent MICA-enhanced MR imaging were enrolled. The dentate nucleus-to-pons (DN/P) and globus pallidus-to-thalamus (GP/Th) signal intensity (SI) ratios on unenhanced T1-weighted images were recorded by 2 independent readers and averaged. The mean DN/P and GP/Th SI ratio difference between the last and the first examinations were tested using the one-sample t-test. Student’s t-test and stepwise regression analysis were used to identify the predisposing factors for deposition based on the number of administrations, time interval, hepatic and renal function, magnetic field strength, and chemo- or radiation therapy. RESULTS: The mean DN/P SI ratio difference was not different from zero (P = .697), even in patients with ≥20 administrations (n = 33). Only patients with abnormal renal function showed an increase in the mean DN/P SI ratio difference (P = .019). The mean DN/P SI ratio difference was not associated with any predisposing factors. However, the mean GP/Th SI ratio difference showed decrease (P < .001), which was associated with age (P = .007), number of administrations (P = .01) and number of radiation therapy sessions (P = .022) on multivariate analysis. CONCLUSION: Multiple repeated administrations of MICA were not associated with increased T1 signal intensity in deep brain nuclei suggestive of Gd deposition in patients with normal renal function. Public Library of Science 2017-08-31 /pmc/articles/PMC5578663/ /pubmed/28859167 http://dx.doi.org/10.1371/journal.pone.0183916 Text en © 2017 Lee et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lee, Ji Ye
Park, Ji Eun
Kim, Ho Sung
Kim, Seon-Ok
Oh, Joo Young
Shim, Woo Hyun
Jung, Seung Chai
Choi, Choong Gon
Kim, Sang Joon
Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients
title Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients
title_full Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients
title_fullStr Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients
title_full_unstemmed Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients
title_short Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients
title_sort up to 52 administrations of macrocyclic ionic mr contrast agent are not associated with intracranial gadolinium deposition: multifactorial analysis in 385 patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578663/
https://www.ncbi.nlm.nih.gov/pubmed/28859167
http://dx.doi.org/10.1371/journal.pone.0183916
work_keys_str_mv AT leejiye upto52administrationsofmacrocyclicionicmrcontrastagentarenotassociatedwithintracranialgadoliniumdepositionmultifactorialanalysisin385patients
AT parkjieun upto52administrationsofmacrocyclicionicmrcontrastagentarenotassociatedwithintracranialgadoliniumdepositionmultifactorialanalysisin385patients
AT kimhosung upto52administrationsofmacrocyclicionicmrcontrastagentarenotassociatedwithintracranialgadoliniumdepositionmultifactorialanalysisin385patients
AT kimseonok upto52administrationsofmacrocyclicionicmrcontrastagentarenotassociatedwithintracranialgadoliniumdepositionmultifactorialanalysisin385patients
AT ohjooyoung upto52administrationsofmacrocyclicionicmrcontrastagentarenotassociatedwithintracranialgadoliniumdepositionmultifactorialanalysisin385patients
AT shimwoohyun upto52administrationsofmacrocyclicionicmrcontrastagentarenotassociatedwithintracranialgadoliniumdepositionmultifactorialanalysisin385patients
AT jungseungchai upto52administrationsofmacrocyclicionicmrcontrastagentarenotassociatedwithintracranialgadoliniumdepositionmultifactorialanalysisin385patients
AT choichoonggon upto52administrationsofmacrocyclicionicmrcontrastagentarenotassociatedwithintracranialgadoliniumdepositionmultifactorialanalysisin385patients
AT kimsangjoon upto52administrationsofmacrocyclicionicmrcontrastagentarenotassociatedwithintracranialgadoliniumdepositionmultifactorialanalysisin385patients