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mlh3 mutations in baker’s yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide

Mlh1-Mlh3 is an endonuclease hypothesized to act in meiosis to resolve double Holliday junctions into crossovers. It also plays a minor role in eukaryotic DNA mismatch repair (MMR). To understand how Mlh1-Mlh3 functions in both meiosis and MMR, we analyzed in baker’s yeast 60 new mlh3 alleles. Five...

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Detalles Bibliográficos
Autores principales:	Al-Sweel, Najla, Raghavan, Vandana, Dutta, Abhishek, Ajith, V. P., Di Vietro, Luigi, Khondakar, Nabila, Manhart, Carol M., Surtees, Jennifer A., Nishant, K. T., Alani, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578695/ https://www.ncbi.nlm.nih.gov/pubmed/28827832 http://dx.doi.org/10.1371/journal.pgen.1006974

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