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The expression of established cognitive brain states stabilizes with working memory development
We present results from a longitudinal study conducted over 10 years in a sample of 126 8–33 year olds demonstrating that adolescent development of working memory is supported by decreased variability in the amplitude of expression of whole brain states of task-related activity. fMRI analyses reveal...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578740/ https://www.ncbi.nlm.nih.gov/pubmed/28826493 http://dx.doi.org/10.7554/eLife.25606 |
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author | Montez, David Florentino Calabro, Finnegan J Luna, Beatriz |
author_facet | Montez, David Florentino Calabro, Finnegan J Luna, Beatriz |
author_sort | Montez, David Florentino |
collection | PubMed |
description | We present results from a longitudinal study conducted over 10 years in a sample of 126 8–33 year olds demonstrating that adolescent development of working memory is supported by decreased variability in the amplitude of expression of whole brain states of task-related activity. fMRI analyses reveal that putative gain signals affecting maintenance and retrieval aspects of working memory processing stabilize during adolescence, while those affecting sensorimotor processes do not. We show that trial-to-trial variability in the reaction time and accuracy of eye-movements during a memory guided saccade task are related to fluctuations in the amplitude of expression of task-related brain states, or brain state variability, and also provide evidence that individual developmental trajectories of reaction time variability are related to individual trajectories of brain state variability. These observations demonstrate that the stabilization of widespread gain signals affecting already available cognitive processes underlies the maturation of cognition during adolescence. |
format | Online Article Text |
id | pubmed-5578740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55787402017-09-01 The expression of established cognitive brain states stabilizes with working memory development Montez, David Florentino Calabro, Finnegan J Luna, Beatriz eLife Human Biology and Medicine We present results from a longitudinal study conducted over 10 years in a sample of 126 8–33 year olds demonstrating that adolescent development of working memory is supported by decreased variability in the amplitude of expression of whole brain states of task-related activity. fMRI analyses reveal that putative gain signals affecting maintenance and retrieval aspects of working memory processing stabilize during adolescence, while those affecting sensorimotor processes do not. We show that trial-to-trial variability in the reaction time and accuracy of eye-movements during a memory guided saccade task are related to fluctuations in the amplitude of expression of task-related brain states, or brain state variability, and also provide evidence that individual developmental trajectories of reaction time variability are related to individual trajectories of brain state variability. These observations demonstrate that the stabilization of widespread gain signals affecting already available cognitive processes underlies the maturation of cognition during adolescence. eLife Sciences Publications, Ltd 2017-08-19 /pmc/articles/PMC5578740/ /pubmed/28826493 http://dx.doi.org/10.7554/eLife.25606 Text en © 2017, Montez et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Human Biology and Medicine Montez, David Florentino Calabro, Finnegan J Luna, Beatriz The expression of established cognitive brain states stabilizes with working memory development |
title | The expression of established cognitive brain states stabilizes with working memory development |
title_full | The expression of established cognitive brain states stabilizes with working memory development |
title_fullStr | The expression of established cognitive brain states stabilizes with working memory development |
title_full_unstemmed | The expression of established cognitive brain states stabilizes with working memory development |
title_short | The expression of established cognitive brain states stabilizes with working memory development |
title_sort | expression of established cognitive brain states stabilizes with working memory development |
topic | Human Biology and Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578740/ https://www.ncbi.nlm.nih.gov/pubmed/28826493 http://dx.doi.org/10.7554/eLife.25606 |
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