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SIRT6 promotes osteogenic differentiation of mesenchymal stem cells through BMP signaling

SIRT6 has been identified as an H3K9 deacetylase and a critical regulator of genome stability, telomere integrity, and metabolic homeostasis. Sirt6-deficient mice displayed dramatic phenotypes including profound lymphopenia, loss of subcutaneous fat, lordokyphosis and low bone marrow density. Here,...

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Detalles Bibliográficos
Autores principales:	Zhang, Ping, Liu, Yunsong, Wang, Yuejun, Zhang, Min, Lv, Longwei, Zhang, Xiao, Zhou, Yongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578964/ https://www.ncbi.nlm.nih.gov/pubmed/28860594 http://dx.doi.org/10.1038/s41598-017-10323-z

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