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Delay discounting is associated with the fractional amplitude of low-frequency fluctuations and resting-state functional connectivity in late adolescence

As a component of self-regulation, delay discounting (DD) refers to an individual’s tendency to prefer smaller-but-sooner rewards over larger-but-later rewards and plays an essential role in many aspects of human behavior. Although numerous studies have examined the neural underpinnings of DD in adu...

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Autores principales: Wang, Song, Zhou, Ming, Chen, Taolin, Yang, Xun, Chen, Guangxiang, Gong, Qiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579001/
https://www.ncbi.nlm.nih.gov/pubmed/28860514
http://dx.doi.org/10.1038/s41598-017-11109-z
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author Wang, Song
Zhou, Ming
Chen, Taolin
Yang, Xun
Chen, Guangxiang
Gong, Qiyong
author_facet Wang, Song
Zhou, Ming
Chen, Taolin
Yang, Xun
Chen, Guangxiang
Gong, Qiyong
author_sort Wang, Song
collection PubMed
description As a component of self-regulation, delay discounting (DD) refers to an individual’s tendency to prefer smaller-but-sooner rewards over larger-but-later rewards and plays an essential role in many aspects of human behavior. Although numerous studies have examined the neural underpinnings of DD in adults, there are far fewer studies focusing on the neurobiological correlates underlying DD in adolescents. Here, we investigated the associations between individual differences in DD and the fractional amplitude of low-frequency fluctuations (fALFF) and resting-state functional connectivity (RSFC) in 228 high school students using resting-state functional magnetic resonance imaging (RS-fMRI). At the regional level, we found an association between higher DD and greater fALFF in the dorsal anterior cingulate cortex (dACC), which is involved in conflict monitoring and strategy adaptation. At the connectivity level, DD was positively correlated with the RSFC between the dACC and the left dorsolateral prefrontal cortex (DLPFC), a critical functional circuit in the cognitive control network. Furthermore, these effects persisted even after adjusting for the influences of general intelligence and trait impulsivity. Overall, this study reveals the fALFF and RSFC as the functional brain basis of DD in late adolescents, aiding to strengthen and corroborate our understanding of the neural underpinnings of DD.
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spelling pubmed-55790012017-09-06 Delay discounting is associated with the fractional amplitude of low-frequency fluctuations and resting-state functional connectivity in late adolescence Wang, Song Zhou, Ming Chen, Taolin Yang, Xun Chen, Guangxiang Gong, Qiyong Sci Rep Article As a component of self-regulation, delay discounting (DD) refers to an individual’s tendency to prefer smaller-but-sooner rewards over larger-but-later rewards and plays an essential role in many aspects of human behavior. Although numerous studies have examined the neural underpinnings of DD in adults, there are far fewer studies focusing on the neurobiological correlates underlying DD in adolescents. Here, we investigated the associations between individual differences in DD and the fractional amplitude of low-frequency fluctuations (fALFF) and resting-state functional connectivity (RSFC) in 228 high school students using resting-state functional magnetic resonance imaging (RS-fMRI). At the regional level, we found an association between higher DD and greater fALFF in the dorsal anterior cingulate cortex (dACC), which is involved in conflict monitoring and strategy adaptation. At the connectivity level, DD was positively correlated with the RSFC between the dACC and the left dorsolateral prefrontal cortex (DLPFC), a critical functional circuit in the cognitive control network. Furthermore, these effects persisted even after adjusting for the influences of general intelligence and trait impulsivity. Overall, this study reveals the fALFF and RSFC as the functional brain basis of DD in late adolescents, aiding to strengthen and corroborate our understanding of the neural underpinnings of DD. Nature Publishing Group UK 2017-08-31 /pmc/articles/PMC5579001/ /pubmed/28860514 http://dx.doi.org/10.1038/s41598-017-11109-z Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wang, Song
Zhou, Ming
Chen, Taolin
Yang, Xun
Chen, Guangxiang
Gong, Qiyong
Delay discounting is associated with the fractional amplitude of low-frequency fluctuations and resting-state functional connectivity in late adolescence
title Delay discounting is associated with the fractional amplitude of low-frequency fluctuations and resting-state functional connectivity in late adolescence
title_full Delay discounting is associated with the fractional amplitude of low-frequency fluctuations and resting-state functional connectivity in late adolescence
title_fullStr Delay discounting is associated with the fractional amplitude of low-frequency fluctuations and resting-state functional connectivity in late adolescence
title_full_unstemmed Delay discounting is associated with the fractional amplitude of low-frequency fluctuations and resting-state functional connectivity in late adolescence
title_short Delay discounting is associated with the fractional amplitude of low-frequency fluctuations and resting-state functional connectivity in late adolescence
title_sort delay discounting is associated with the fractional amplitude of low-frequency fluctuations and resting-state functional connectivity in late adolescence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579001/
https://www.ncbi.nlm.nih.gov/pubmed/28860514
http://dx.doi.org/10.1038/s41598-017-11109-z
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