Development of a novel and cost-effective redox sensor for voltammetric determination of pantoprazole sodium during pharmacokinetic studies

A pencil graphite electrode modified with poly (bromocresol green (BCG)) was prepared by electro-polymerization process for the determination of pantoprazole sodium. The surface morphology and structure of poly (BCG) film were characterized by scanning electron microscopy and Fourier transform infra...

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Autores principales: Khashaba, Pakinaz Y., Ali, Hassan Refat H., El-wekil, Mohamed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579098/
https://www.ncbi.nlm.nih.gov/pubmed/28878983
http://dx.doi.org/10.1098/rsos.170324
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author Khashaba, Pakinaz Y.
Ali, Hassan Refat H.
El-wekil, Mohamed M.
author_facet Khashaba, Pakinaz Y.
Ali, Hassan Refat H.
El-wekil, Mohamed M.
author_sort Khashaba, Pakinaz Y.
collection PubMed
description A pencil graphite electrode modified with poly (bromocresol green (BCG)) was prepared by electro-polymerization process for the determination of pantoprazole sodium. The surface morphology and structure of poly (BCG) film were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The determination of pantoprazole sodium in Britton–Robinson buffer (pH 7.0) was carried out by square wave adsorptive stripping voltammetric technique. Under optimum conditions, the linear response of the peak with concentration of the cited drug was in the range of 6.6–360 × 10(−8 )M with limit of detection of 2.2 × 10(−8 )M. Moreover, the poly (BCG)-modified electrode has been successfully applied to determine pantoprazole sodium in tablets, vials and during pharmacokinetic studies.
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spelling pubmed-55790982017-09-06 Development of a novel and cost-effective redox sensor for voltammetric determination of pantoprazole sodium during pharmacokinetic studies Khashaba, Pakinaz Y. Ali, Hassan Refat H. El-wekil, Mohamed M. R Soc Open Sci Chemistry A pencil graphite electrode modified with poly (bromocresol green (BCG)) was prepared by electro-polymerization process for the determination of pantoprazole sodium. The surface morphology and structure of poly (BCG) film were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. The determination of pantoprazole sodium in Britton–Robinson buffer (pH 7.0) was carried out by square wave adsorptive stripping voltammetric technique. Under optimum conditions, the linear response of the peak with concentration of the cited drug was in the range of 6.6–360 × 10(−8 )M with limit of detection of 2.2 × 10(−8 )M. Moreover, the poly (BCG)-modified electrode has been successfully applied to determine pantoprazole sodium in tablets, vials and during pharmacokinetic studies. The Royal Society Publishing 2017-08-09 /pmc/articles/PMC5579098/ /pubmed/28878983 http://dx.doi.org/10.1098/rsos.170324 Text en © 2017 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Khashaba, Pakinaz Y.
Ali, Hassan Refat H.
El-wekil, Mohamed M.
Development of a novel and cost-effective redox sensor for voltammetric determination of pantoprazole sodium during pharmacokinetic studies
title Development of a novel and cost-effective redox sensor for voltammetric determination of pantoprazole sodium during pharmacokinetic studies
title_full Development of a novel and cost-effective redox sensor for voltammetric determination of pantoprazole sodium during pharmacokinetic studies
title_fullStr Development of a novel and cost-effective redox sensor for voltammetric determination of pantoprazole sodium during pharmacokinetic studies
title_full_unstemmed Development of a novel and cost-effective redox sensor for voltammetric determination of pantoprazole sodium during pharmacokinetic studies
title_short Development of a novel and cost-effective redox sensor for voltammetric determination of pantoprazole sodium during pharmacokinetic studies
title_sort development of a novel and cost-effective redox sensor for voltammetric determination of pantoprazole sodium during pharmacokinetic studies
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579098/
https://www.ncbi.nlm.nih.gov/pubmed/28878983
http://dx.doi.org/10.1098/rsos.170324
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