Zoledronic acid renders human M1 and M2 macrophages susceptible to Vδ2(+) γδ T cell cytotoxicity in a perforin-dependent manner

Vδ2(+) T cells are a subpopulation of γδ T cells in humans that are cytotoxic towards cells which accumulate isopentenyl pyrophosphate. The nitrogen-containing bisphosphonate, zoledronic acid (ZA), can induce tumour cell lines to accumulate isopentenyl pyrophosphate, thus rendering them more suscept...

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Detalles Bibliográficos
Autores principales: Fowler, Daniel W., Copier, John, Dalgleish, Angus G., Bodman-Smith, Mark D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579165/
https://www.ncbi.nlm.nih.gov/pubmed/28501938
http://dx.doi.org/10.1007/s00262-017-2011-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579165/
https://www.ncbi.nlm.nih.gov/pubmed/28501938
http://dx.doi.org/10.1007/s00262-017-2011-1

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