De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide

Computational antibody engineering efforts to date have focused on improving binding affinities or biophysical characteristics. De novo design of antibodies binding specific epitopes could greatly accelerate discovery of therapeutics as compared to conventional immunization or synthetic library sele...

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Detalles Bibliográficos
Autores principales: Entzminger, Kevin C., Hyun, Jeong-min, Pantazes, Robert J., Patterson-Orazem, Athena C., Qerqez, Ahlam N., Frye, Zach P., Hughes, Randall A., Ellington, Andrew D., Lieberman, Raquel L., Maranas, Costas D., Maynard, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579192/
https://www.ncbi.nlm.nih.gov/pubmed/28860479
http://dx.doi.org/10.1038/s41598-017-10737-9

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