Cargando…

Detection of dynamic substrate binding using MRI

Magnetic Resonance Imaging (MRI) is rarely used for molecular binding studies and never without synthetic metallic labels. We designed an MRI approach that can specifically detect the binding of natural substrates (i.e. no chemical labels). To accomplish such detection of substrate-target interactio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yadav, Nirbhay N., Yang, Xing, Li, Yuguo, Li, Wenbo, Liu, Guanshu, van Zijl, Peter C. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579242/ https://www.ncbi.nlm.nih.gov/pubmed/28860625 http://dx.doi.org/10.1038/s41598-017-10545-1

Ejemplares similares

A dextran-based probe for the targeted magnetic resonance imaging of tumours expressing prostate-specific membrane antigen
por: Liu, Guanshu, et al.
Publicado: (2017)

Detection of electrostatic molecular binding using the water proton signal
por: Zhou, Yang, et al.
Publicado: (2022)

Label-free CEST MRI Detection of Citicoline-Liposome Drug Delivery in Ischemic Stroke
por: Liu, Huanling, et al.
Publicado: (2016)

CEST theranostics: label-free MR imaging of anticancer drugs
por: Li, Yuguo, et al.
Publicado: (2016)

Dynamic Glucose-Enhanced (DGE) MRI: Translation to Human Scanning and First Results in Glioma Patients
por: Xu, Xiang, et al.
Publicado: (2015)

Single (19)F Probe for Simultaneous Detection of Multiple Metal Ions Using miCEST MRI
por: Bar-Shir, Amnon, et al.
Publicado: (2014)

Deuterium oxide as a contrast medium for real-time MRI-guided endovascular neurointervention
por: Chen, Lin, et al.
Publicado: (2021)

Highly efficient magnetic labelling allows MRI tracking of the homing of stem cell‐derived extracellular vesicles following systemic delivery
por: Han, Zheng, et al.
Publicado: (2021)

MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted cell viability
por: Chan, Kannie W.Y., et al.
Publicado: (2013)

Cardiac CEST-MRI for tracking stem cell survival and determining the role of CXCL2
por: Alon, Lina, et al.
Publicado: (2016)

MRI Detection of Hepatic N-Acetylcysteine Uptake in Mice
por: Chen, Johnny, et al.
Publicado: (2022)

T(2)‐oximetry–based cerebral venous oxygenation mapping using Fourier‐transform–based velocity‐selective pulse trains
por: Li, Wenbo, et al.
Publicado: (2022)

Dynamic Susceptibility Contrast MRI at 7 T: Tail-Scaling Analysis and Inferences About Field Strength Dependence
por: Knutsson, Linda, et al.
Publicado: (2017)

Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI
por: Huang, Jianpan, et al.
Publicado: (2020)

Dynamic allostery in substrate binding by human thymidylate synthase
por: Bonin, Jeffrey P, et al.
Publicado: (2022)

Observing spontaneous, accelerated substrate binding in molecular dynamics simulations of glutamate transporters
por: Wang, Jiali, et al.
Publicado: (2021)

Label-Free Assessment of Mannitol Accumulation Following Osmotic Blood–Brain Barrier Opening Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging
por: Liu, Jing, et al.
Publicado: (2022)

In Vivo Biomarker Imaging: Paving the Way for Precision Medicine
por: Liu, Guanshu, et al.
Publicado: (2023)

Real-Time MRI Guidance for Reproducible Hyperosmolar Opening of the Blood-Brain Barrier in Mice
por: Chu, Chengyan, et al.
Publicado: (2018)

Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFR
por: Sittikornpaiboon, Pimonluck, et al.
Publicado: (2017)

Dynamics of Scabin toxin. A proposal for the binding mode of the DNA substrate
por: Lugo, Miguel R., et al.
Publicado: (2018)

Conformational dynamics of the human serotonin transporter during substrate and drug binding
por: Möller, Ingvar R., et al.
Publicado: (2019)

Functional Activities Detected in the Olfactory Bulb and Associated Olfactory Regions in the Human Brain Using T2-Prepared BOLD Functional MRI at 7T
por: Miao, Xinyuan, et al.
Publicado: (2021)

Neural Substrates of Word Generation during Stroke Recovery: The Influence of Cortical Hypoperfusion
por: Prabhakaran, V., et al.
Publicado: (2007)

Using network dynamic fMRI for detection of epileptogenic foci
por: Nedic, Sanja, et al.
Publicado: (2015)

Modelling of substrate access and substrate binding to cephalosporin acylases
por: Ferrario, Valerio, et al.
Publicado: (2019)

Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations
por: Gabrielsen, Mari, et al.
Publicado: (2011)

Substrate Binding Stiffens Aspartate Aminotransferase by Altering the Enzyme Picosecond Vibrational Dynamics
por: Dajnowicz, Steven, et al.
Publicado: (2020)

Polymorphism on human aromatase affects protein dynamics and substrate binding: spectroscopic evidence
por: Di Nardo, Giovanna, et al.
Publicado: (2021)

Faded Critical Dynamics in Adult Moyamoya Disease Revealed by EEG and fMRI
por: Lei, Yu, et al.
Publicado: (2021)

An Effective Approach for Clustering InhA Molecular Dynamics Trajectory Using Substrate-Binding Cavity Features
por: De Paris, Renata, et al.
Publicado: (2015)

DNA sequencing using polymerase substrate-binding kinetics
por: Previte, Michael John Robert, et al.
Publicado: (2015)

Ligand binding and global adaptation of the GlnPQ substrate binding domain 2 revealed by molecular dynamics simulations
por: Kienlein, Maximilian, et al.
Publicado: (2020)

Protocol for detecting substrates in living cells by targeted molecular probes through hyperpolarized (129)Xe MRI
por: Zeng, Qingbin, et al.
Publicado: (2022)

Study of Endogen Substrates, Drug Substrates and Inhibitors Binding Conformations on MRP4 and Its Variants by Molecular Docking and Molecular Dynamics
por: Becerra, Edgardo, et al.
Publicado: (2021)

Binding Affinity Determines Substrate Specificity and Enables Discovery of Substrates for N-Myristoyltransferases
por: Su, Dan, et al.
Publicado: (2021)

Far-western Blotting Detection of the Binding of Insulin Receptor Substrate to the Insulin Receptor
por: Peng, Jinghua, et al.
Publicado: (2023)

Unieke situatie vraagt onconventionele aanpak
por: van Zijl, Peter
Publicado: (2020)

Trots op onze helden
por: van Zijl, Peter
Publicado: (2020)

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate
por: Madoux, Franck, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_v9n58b1v6t3skllbr9veq2l4vi