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Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma

Fraction of exhaled nitric oxide (FeNO) provides information about chronic inflammation in asthma. However, its relationship with structural changes in the airways is unknown. We aimed to evaluate the correlation between computer-based airway changes and FeNO in patients with asthma. The wall area (...

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Autores principales: Nishimoto, Koji, Karayama, Masato, Inui, Naoki, Mori, Kazutaka, Kono, Masato, Hozumi, Hironao, Suzuki, Yuzo, Furuhashi, Kazuki, Enomoto, Noriyuki, Fujisawa, Tomoyuki, Nakamura, Yutaro, Watanabe, Hiroshi, Suda, Takafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579255/
https://www.ncbi.nlm.nih.gov/pubmed/28860527
http://dx.doi.org/10.1038/s41598-017-10504-w
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author Nishimoto, Koji
Karayama, Masato
Inui, Naoki
Mori, Kazutaka
Kono, Masato
Hozumi, Hironao
Suzuki, Yuzo
Furuhashi, Kazuki
Enomoto, Noriyuki
Fujisawa, Tomoyuki
Nakamura, Yutaro
Watanabe, Hiroshi
Suda, Takafumi
author_facet Nishimoto, Koji
Karayama, Masato
Inui, Naoki
Mori, Kazutaka
Kono, Masato
Hozumi, Hironao
Suzuki, Yuzo
Furuhashi, Kazuki
Enomoto, Noriyuki
Fujisawa, Tomoyuki
Nakamura, Yutaro
Watanabe, Hiroshi
Suda, Takafumi
author_sort Nishimoto, Koji
collection PubMed
description Fraction of exhaled nitric oxide (FeNO) provides information about chronic inflammation in asthma. However, its relationship with structural changes in the airways is unknown. We aimed to evaluate the correlation between computer-based airway changes and FeNO in patients with asthma. The wall area (WA) and airway inner luminal area (Ai) of the third- to sixth-generation bronchi were measured using three-dimensional computed tomography in asthmatic patients. Each value was corrected by body surface area (BSA). Relationships between FeNO and WA/BSA and Ai/BSA were evaluated. Forty-one clinically stable patients with asthma were evaluated. FeNO was significantly correlated with WA/BSA of the third-, fourth-, fifth- and sixth-generation bronchi (Spearman correlation coefficient (ρ) = 0.326, p = 0.041; ρ = 0.356, p = 0.025; ρ = 0.496, p = 0.002; and ρ = 0.529, p < 0.001, respectively). The correlation with sixth-generation bronchi was significantly greater than with the third-generation bronchi (p = 0.047). Partial rank correlation analysis indicated FeNO was significantly correlated with WA/BSA of the sixth-generation bronchi, independent from confounding factors of Ai/BSA, age, duration of asthma, dose of inhaled corticosteroid, blood eosinophil percentage, and blood IgE (ρ = 0.360, p = 0.034). In contrast, there was no correlation between FeNO and Ai/BSA. FeNO correlates with bronchial wall thickening in asthma patients. Measurement of FeNO may be useful to detect airway remodeling in asthma.
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spelling pubmed-55792552017-09-06 Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma Nishimoto, Koji Karayama, Masato Inui, Naoki Mori, Kazutaka Kono, Masato Hozumi, Hironao Suzuki, Yuzo Furuhashi, Kazuki Enomoto, Noriyuki Fujisawa, Tomoyuki Nakamura, Yutaro Watanabe, Hiroshi Suda, Takafumi Sci Rep Article Fraction of exhaled nitric oxide (FeNO) provides information about chronic inflammation in asthma. However, its relationship with structural changes in the airways is unknown. We aimed to evaluate the correlation between computer-based airway changes and FeNO in patients with asthma. The wall area (WA) and airway inner luminal area (Ai) of the third- to sixth-generation bronchi were measured using three-dimensional computed tomography in asthmatic patients. Each value was corrected by body surface area (BSA). Relationships between FeNO and WA/BSA and Ai/BSA were evaluated. Forty-one clinically stable patients with asthma were evaluated. FeNO was significantly correlated with WA/BSA of the third-, fourth-, fifth- and sixth-generation bronchi (Spearman correlation coefficient (ρ) = 0.326, p = 0.041; ρ = 0.356, p = 0.025; ρ = 0.496, p = 0.002; and ρ = 0.529, p < 0.001, respectively). The correlation with sixth-generation bronchi was significantly greater than with the third-generation bronchi (p = 0.047). Partial rank correlation analysis indicated FeNO was significantly correlated with WA/BSA of the sixth-generation bronchi, independent from confounding factors of Ai/BSA, age, duration of asthma, dose of inhaled corticosteroid, blood eosinophil percentage, and blood IgE (ρ = 0.360, p = 0.034). In contrast, there was no correlation between FeNO and Ai/BSA. FeNO correlates with bronchial wall thickening in asthma patients. Measurement of FeNO may be useful to detect airway remodeling in asthma. Nature Publishing Group UK 2017-08-31 /pmc/articles/PMC5579255/ /pubmed/28860527 http://dx.doi.org/10.1038/s41598-017-10504-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Nishimoto, Koji
Karayama, Masato
Inui, Naoki
Mori, Kazutaka
Kono, Masato
Hozumi, Hironao
Suzuki, Yuzo
Furuhashi, Kazuki
Enomoto, Noriyuki
Fujisawa, Tomoyuki
Nakamura, Yutaro
Watanabe, Hiroshi
Suda, Takafumi
Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma
title Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma
title_full Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma
title_fullStr Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma
title_full_unstemmed Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma
title_short Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma
title_sort relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional ct analysis in asthma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579255/
https://www.ncbi.nlm.nih.gov/pubmed/28860527
http://dx.doi.org/10.1038/s41598-017-10504-w
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