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Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma
Fraction of exhaled nitric oxide (FeNO) provides information about chronic inflammation in asthma. However, its relationship with structural changes in the airways is unknown. We aimed to evaluate the correlation between computer-based airway changes and FeNO in patients with asthma. The wall area (...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579255/ https://www.ncbi.nlm.nih.gov/pubmed/28860527 http://dx.doi.org/10.1038/s41598-017-10504-w |
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author | Nishimoto, Koji Karayama, Masato Inui, Naoki Mori, Kazutaka Kono, Masato Hozumi, Hironao Suzuki, Yuzo Furuhashi, Kazuki Enomoto, Noriyuki Fujisawa, Tomoyuki Nakamura, Yutaro Watanabe, Hiroshi Suda, Takafumi |
author_facet | Nishimoto, Koji Karayama, Masato Inui, Naoki Mori, Kazutaka Kono, Masato Hozumi, Hironao Suzuki, Yuzo Furuhashi, Kazuki Enomoto, Noriyuki Fujisawa, Tomoyuki Nakamura, Yutaro Watanabe, Hiroshi Suda, Takafumi |
author_sort | Nishimoto, Koji |
collection | PubMed |
description | Fraction of exhaled nitric oxide (FeNO) provides information about chronic inflammation in asthma. However, its relationship with structural changes in the airways is unknown. We aimed to evaluate the correlation between computer-based airway changes and FeNO in patients with asthma. The wall area (WA) and airway inner luminal area (Ai) of the third- to sixth-generation bronchi were measured using three-dimensional computed tomography in asthmatic patients. Each value was corrected by body surface area (BSA). Relationships between FeNO and WA/BSA and Ai/BSA were evaluated. Forty-one clinically stable patients with asthma were evaluated. FeNO was significantly correlated with WA/BSA of the third-, fourth-, fifth- and sixth-generation bronchi (Spearman correlation coefficient (ρ) = 0.326, p = 0.041; ρ = 0.356, p = 0.025; ρ = 0.496, p = 0.002; and ρ = 0.529, p < 0.001, respectively). The correlation with sixth-generation bronchi was significantly greater than with the third-generation bronchi (p = 0.047). Partial rank correlation analysis indicated FeNO was significantly correlated with WA/BSA of the sixth-generation bronchi, independent from confounding factors of Ai/BSA, age, duration of asthma, dose of inhaled corticosteroid, blood eosinophil percentage, and blood IgE (ρ = 0.360, p = 0.034). In contrast, there was no correlation between FeNO and Ai/BSA. FeNO correlates with bronchial wall thickening in asthma patients. Measurement of FeNO may be useful to detect airway remodeling in asthma. |
format | Online Article Text |
id | pubmed-5579255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55792552017-09-06 Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma Nishimoto, Koji Karayama, Masato Inui, Naoki Mori, Kazutaka Kono, Masato Hozumi, Hironao Suzuki, Yuzo Furuhashi, Kazuki Enomoto, Noriyuki Fujisawa, Tomoyuki Nakamura, Yutaro Watanabe, Hiroshi Suda, Takafumi Sci Rep Article Fraction of exhaled nitric oxide (FeNO) provides information about chronic inflammation in asthma. However, its relationship with structural changes in the airways is unknown. We aimed to evaluate the correlation between computer-based airway changes and FeNO in patients with asthma. The wall area (WA) and airway inner luminal area (Ai) of the third- to sixth-generation bronchi were measured using three-dimensional computed tomography in asthmatic patients. Each value was corrected by body surface area (BSA). Relationships between FeNO and WA/BSA and Ai/BSA were evaluated. Forty-one clinically stable patients with asthma were evaluated. FeNO was significantly correlated with WA/BSA of the third-, fourth-, fifth- and sixth-generation bronchi (Spearman correlation coefficient (ρ) = 0.326, p = 0.041; ρ = 0.356, p = 0.025; ρ = 0.496, p = 0.002; and ρ = 0.529, p < 0.001, respectively). The correlation with sixth-generation bronchi was significantly greater than with the third-generation bronchi (p = 0.047). Partial rank correlation analysis indicated FeNO was significantly correlated with WA/BSA of the sixth-generation bronchi, independent from confounding factors of Ai/BSA, age, duration of asthma, dose of inhaled corticosteroid, blood eosinophil percentage, and blood IgE (ρ = 0.360, p = 0.034). In contrast, there was no correlation between FeNO and Ai/BSA. FeNO correlates with bronchial wall thickening in asthma patients. Measurement of FeNO may be useful to detect airway remodeling in asthma. Nature Publishing Group UK 2017-08-31 /pmc/articles/PMC5579255/ /pubmed/28860527 http://dx.doi.org/10.1038/s41598-017-10504-w Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Nishimoto, Koji Karayama, Masato Inui, Naoki Mori, Kazutaka Kono, Masato Hozumi, Hironao Suzuki, Yuzo Furuhashi, Kazuki Enomoto, Noriyuki Fujisawa, Tomoyuki Nakamura, Yutaro Watanabe, Hiroshi Suda, Takafumi Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma |
title | Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma |
title_full | Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma |
title_fullStr | Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma |
title_full_unstemmed | Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma |
title_short | Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma |
title_sort | relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional ct analysis in asthma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579255/ https://www.ncbi.nlm.nih.gov/pubmed/28860527 http://dx.doi.org/10.1038/s41598-017-10504-w |
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