Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration

Wolfram syndrome (WS) is a rare autosomal-recessive disorder that is caused by mutations in the WFS1 gene and is characterized by juvenile-onset diabetes, optic atrophy, hearing loss and a number of other complications. Here, we describe the creation and phenotype of Wfs1 mutant rats, in which exon...

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Detalles Bibliográficos
Autores principales: Plaas, Mario, Seppa, Kadri, Reimets, Riin, Jagomäe, Toomas, Toots, Maarja, Koppel, Tuuliki, Vallisoo, Tuuli, Nigul, Mait, Heinla, Indrek, Meier, Riho, Kaasik, Allen, Piirsoo, Andres, Hickey, Miriam A., Terasmaa, Anton, Vasar, Eero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579261/
https://www.ncbi.nlm.nih.gov/pubmed/28860598
http://dx.doi.org/10.1038/s41598-017-09392-x

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