Cargando…

Dose optimisation of intravenous tranexamic acid for elective hip and knee arthroplasty: The effectiveness of a single pre-operative dose

OBJECTIVES: We have increased the dose of tranexamic acid (TXA) in our enhanced total joint recovery protocol at our institution from 15 mg/kg to 30 mg/kg (maximum 2.5 g) as a single, intravenous (IV) dose. We report the clinical effect of this dosage change. METHODS: We retrospectively compared two...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morrison, R. J. M., Tsang, B., Fishley, W., Harper, I., Joseph, J. C., Reed, M. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579309/ https://www.ncbi.nlm.nih.gov/pubmed/28851694 http://dx.doi.org/10.1302/2046-3758.68.BJR-2017-0005.R1

Ejemplares similares

Efficacy and safety of single- and double-dose intravenous tranexamic acid in hip and knee arthroplasty: a systematic review and meta-analysis
por: Yang, Yong-Ze, et al.
Publicado: (2023)

The effect of vitamin D supplementation on outcomes following total hip or knee arthroplasty surgery: a rapid systematic review of current evidence
por: Morrison, R J M, et al.
Publicado: (2022)

Tranexamic acid is effective in lower doses with infusion in total knee arthroplasty
por: Aytuluk, Hande Gurbuz, et al.
Publicado: (2019)

Additional Dose of Intravenous Tranexamic Acid after Primary Total Knee Arthroplasty Further Reduces Hidden Blood Loss
por: Li, Zi-Jian, et al.
Publicado: (2018)

Multiple intravenous tranexamic acid doses in total knee arthroplasty in patients with rheumatoid arthritis: a randomized controlled study
por: Kang, Bing-xin, et al.
Publicado: (2021)

Comparison of intravenous and topical tranexamic acid in total knee arthroplasty
por: Wei, Wenbo, et al.
Publicado: (2018)

Intravenous Use of Tranexamic Acid in Total Knee Arthroplasty with no Tourniquet
por: Cavalli, Filipe Steimbach, et al.
Publicado: (2023)

Efficacy of a three-day prolonged-course of multiple-dose versus a single-dose of tranexamic acid in total hip and knee arthroplasty
por: Wu, Xiang-Dong, et al.
Publicado: (2020)

Effect of Multiple Doses of Intravenous Tranexamic Acid on Perioperative Blood Loss in Total Knee Arthroplasty: A Randomized Controlled Study
por: Kang, Bing‐xin, et al.
Publicado: (2020)

Can technology optimise the pre-operative pathway for elective hip and knee replacement surgery: a qualitative study
por: Sharif, Faraz, et al.
Publicado: (2020)

Oral vs intravenous tranexamic acid in total-knee arthroplasty and total hip arthroplasty: A systematic review and meta-analysis
por: Chen, Xuanhuang, et al.
Publicado: (2019)

A questionnaire-based survey investigating the current use of tranexamic acid in traumatic haemorrhage and elective hip and knee arthroplasty
por: Young, Ben, et al.
Publicado: (2014)

Perioperative blood loss in total hip and knee arthroplasty: Outcomes associated with intravenous tranexamic acid use in an academic medical center
por: Hogan, Craig A, et al.
Publicado: (2016)

Comparison of oral versus intravenous tranexamic acid in total knee and hip arthroplasty: A GRADE analysis and meta-analysis
por: Sun, Changjiao, et al.
Publicado: (2020)

The Value of Routine Intravenous Tranexamic Acid in Total Hip Arthroplasty: A Preliminary Study
por: Chin, J., et al.
Publicado: (2020)

Combined use of intravenous and topical versus intravenous tranexamic acid in primary total knee and hip arthroplasty: a meta-analysis of randomised controlled trials
por: Li, Jun-feng, et al.
Publicado: (2017)

Low Dose Perioperative Intravenous Tranexamic Acid in Patients Undergoing Total Knee Arthroplasty: A Double-Blind Randomized Placebo Controlled Clinical Trial
por: Motififard, Mahdi, et al.
Publicado: (2015)

Efficacy of preoperative administration of single high dose intravenous tranexamic acid in reducing blood loss in total knee arthroplasty: A prospective clinical study
por: Akgül, Turgut, et al.
Publicado: (2016)

Comparison of Intravenous, Topical, or Combined Routes of Tranexamic Acid in Primary Total Knee Arthroplasty
por: Bi, Chunqiang, et al.
Publicado: (2023)

Blood Loss Control with Two Doses of Tranexamic Acid in a Multimodal Protocol for Total Knee Arthroplasty
por: Ortega-Andreu, Miguel, et al.
Publicado: (2011)

Can Low-dose Tranexamic Acid Decrease Blood Loss and Transfusion Requirements in Total Knee Arthroplasty?
por: Senturk, Ozgur
Publicado: (2018)

Single-dose lidocaine spinal anesthesia in hip and knee arthroplasty
por: Frisch, Nicholas B., et al.
Publicado: (2018)

Is combined topical and intravenous tranexamic acid superior to intravenous tranexamic acid alone for controlling blood loss after total hip arthroplasty?: A meta-analysis
por: Zhang, Hua, et al.
Publicado: (2017)

Assessment of the effect of addition of 24 hours of oral tranexamic acid post-operatively to a single intraoperative intravenous dose of tranexamic acid on calculated blood loss following primary hip and knee arthroplasty (TRAC-24): a study protocol for a randomised controlled trial
por: Hill, Janet, et al.
Publicado: (2018)

A Single Dose Versus Two Doses of Tranexamic Acid for Extracapsular Hip Fractures
por: Jiganti, Max, et al.
Publicado: (2022)

Is There a Synergistic Effect of Topical Plus Intravenous Tranexamic Acid Versus Intravenous Administration Alone on Blood Loss and Transfusions in Primary Total Hip and Knee Arthroplasties?
por: Chalmers, Brian P., et al.
Publicado: (2021)

Tranexamic acid and the reduction of blood loss in total knee and hip arthroplasty: a meta-analysis
por: Gandhi, Rajiv, et al.
Publicado: (2013)

Perioperative intravenous tranexamic acid reduces blood transfusion in primary cementless total hip arthroplasty
por: Andrea, Sandri, et al.
Publicado: (2019)

Comment on: ʺEfficacy of preoperative administration of single high dose intravenous tranexamic acid in reducing blood loss in total knee arthroplasty: A prospective clinical studyʺ
por: Akman, Budak, et al.
Publicado: (2018)

Perioperative Management of Chronic Antithrombotic Agents in Elective Hip and Knee Arthroplasty
por: Santana, Daniel C., et al.
Publicado: (2021)

Effectiveness of pre-operative anaemia screening and increased Tranexamic acid dose policies on outcomes following unilateral primary, elective total hip or knee replacement: a statistical analysis plan for an interrupted time series and regression discontinuity study
por: Scrimshire, Ashley B., et al.
Publicado: (2021)

Is combined use of intravenous and intraarticular tranexamic acid superior to intravenous or intraarticular tranexamic acid alone in total knee arthroplasty? A meta-analysis of randomized controlled trials
por: Mi, Bobin, et al.
Publicado: (2017)

The efficacy of oral versus intravenous tranexamic acid in reducing blood loss after primary total knee and hip arthroplasty: A meta-analysis
por: Wang, Fei, et al.
Publicado: (2018)

Comparison of oral and intravenous tranexamic acid in total hip arthroplasty: a systematic review and meta-analysis
por: Qi, Yiming, et al.
Publicado: (2020)

Incidence, predictors, and timing of post-operative stroke following elective total hip arthroplasty and total knee arthroplasty
por: Haynes, Monique S., et al.
Publicado: (2020)

The combined effect of administration of intravenous and topical tranexamic acid on blood loss and transfusion rate in total knee arthroplasty: Combined tranexamic acid for TKA
por: Yuan, Z. F., et al.
Publicado: (2016)

Tranexamic acid may benefit patients undergoing total hip/knee arthroplasty because of haemophilia
por: Huang, Ze Yu, et al.
Publicado: (2019)

Topical Tranexamic Acid Reduces Postoperative Blood Loss in Primary Total Hip and Knee Arthroplasty
por: Caruthers, Corey M., et al.
Publicado: (2018)

Comparative study of topical vs. intravenous tranexamic acid regarding blood loss in total knee arthroplasty()
por: Zekcer, Ari, et al.
Publicado: (2017)

Ideal intraarticular application dose of tranexamic acid in primary total knee arthroplasty: a prospective, randomized and controlled study
por: Wu, Jun, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_74md18jb743783nq8o0m261fsq