Analysis of mutant allele fractions in driver genes in colorectal cancer – biological and clinical insights

Sequencing of tumors is now routine and guides personalized cancer therapy. Mutant allele fractions (MAFs, or the ‘mutation dose’) of a driver gene may reveal the genomic structure of tumors and influence response to targeted therapies. We performed a comprehensive analysis of MAFs of driver alterat...

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Detalles Bibliográficos
Autores principales: Dienstmann, Rodrigo, Elez, Elena, Argiles, Guillem, Matos, Ignacio, Sanz‐Garcia, Enrique, Ortiz, Carolina, Macarulla, Teresa, Capdevila, Jaume, Alsina, Maria, Sauri, Tamara, Verdaguer, Helena, Vilaro, Marta, Ruiz‐Pace, Fiorella, Viaplana, Cristina, Garcia, Ariadna, Landolfi, Stefania, Palmer, Hector G., Nuciforo, Paolo, Rodon, Jordi, Vivancos, Ana, Tabernero, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579330/
https://www.ncbi.nlm.nih.gov/pubmed/28618197
http://dx.doi.org/10.1002/1878-0261.12099

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