Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis

Nucleic acids are potent triggers for innate immunity. Double‐stranded DNA and RNA adopt different helical conformations, including the unusual Z‐conformation. Z‐DNA/RNA is recognised by Z‐binding domains (ZBDs), which are present in proteins implicated in antiviral immunity. These include ZBP1 (als...

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Detalles Bibliográficos
Autores principales: Maelfait, Jonathan, Liverpool, Layal, Bridgeman, Anne, Ragan, Katherine B, Upton, Jason W, Rehwinkel, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579359/
https://www.ncbi.nlm.nih.gov/pubmed/28716805
http://dx.doi.org/10.15252/embj.201796476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579359/
https://www.ncbi.nlm.nih.gov/pubmed/28716805
http://dx.doi.org/10.15252/embj.201796476

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