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Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women

Obesity is one of the diagnostic criteria of metabolic syndrome (MS). It is correlated with insulin resistance (IR) and high vascular risk as well. Advanced glycation end products (AGEs) and their receptor (RAGE) play an important role in abnormal metabolic components in obese women. This study aime...

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Autores principales: Zaki, Moushira, Kamal, Sanaa, Kholousi, Shams, El-Bassyouni, Hala T., Yousef, Walaa, Reyad, Hanaa, Mohamed, Ramy, Basha, Walaa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579397/
https://www.ncbi.nlm.nih.gov/pubmed/28900377
http://dx.doi.org/10.17179/excli2017-275
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author Zaki, Moushira
Kamal, Sanaa
Kholousi, Shams
El-Bassyouni, Hala T.
Yousef, Walaa
Reyad, Hanaa
Mohamed, Ramy
Basha, Walaa A.
author_facet Zaki, Moushira
Kamal, Sanaa
Kholousi, Shams
El-Bassyouni, Hala T.
Yousef, Walaa
Reyad, Hanaa
Mohamed, Ramy
Basha, Walaa A.
author_sort Zaki, Moushira
collection PubMed
description Obesity is one of the diagnostic criteria of metabolic syndrome (MS). It is correlated with insulin resistance (IR) and high vascular risk as well. Advanced glycation end products (AGEs) and their receptor (RAGE) play an important role in abnormal metabolic components in obese women. This study aimed to explore the serum levels of sRAGE in Egyptian obese women and compare with healthy non-obese controls and investigate the relationship between serum sRAGE, metabolic parameters, and obesity complications. The soluble form of receptor for advanced glycation end products (sRAGE), anthropometry, metabolic and biochemical biomarkers were measured in 100 obese women and 100 age-matched healthy control non-obese women. The homeostasis model assessment estimate of insulin resistance (HOMA-IR) has been determined from serum insulin and glucose values. Serum sRAGE levels were significantly lower in obese cases than controls and inversely correlated with obesity and metabolic parameters. Results of univariate and multivariate analyses for determinants of serum sRAGE levels in obese cases showed that parameters statistically and significantly related were body mass index (BMI), waist circumference (WC), LDL-C, TG, BP, HOMA-IR, ALT and AST. sRAGE is a novel biomarker for metabolic dysfunction in Egyptian obese women and might predict the future cardio-metabolic events.
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spelling pubmed-55793972017-09-12 Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women Zaki, Moushira Kamal, Sanaa Kholousi, Shams El-Bassyouni, Hala T. Yousef, Walaa Reyad, Hanaa Mohamed, Ramy Basha, Walaa A. EXCLI J Original Article Obesity is one of the diagnostic criteria of metabolic syndrome (MS). It is correlated with insulin resistance (IR) and high vascular risk as well. Advanced glycation end products (AGEs) and their receptor (RAGE) play an important role in abnormal metabolic components in obese women. This study aimed to explore the serum levels of sRAGE in Egyptian obese women and compare with healthy non-obese controls and investigate the relationship between serum sRAGE, metabolic parameters, and obesity complications. The soluble form of receptor for advanced glycation end products (sRAGE), anthropometry, metabolic and biochemical biomarkers were measured in 100 obese women and 100 age-matched healthy control non-obese women. The homeostasis model assessment estimate of insulin resistance (HOMA-IR) has been determined from serum insulin and glucose values. Serum sRAGE levels were significantly lower in obese cases than controls and inversely correlated with obesity and metabolic parameters. Results of univariate and multivariate analyses for determinants of serum sRAGE levels in obese cases showed that parameters statistically and significantly related were body mass index (BMI), waist circumference (WC), LDL-C, TG, BP, HOMA-IR, ALT and AST. sRAGE is a novel biomarker for metabolic dysfunction in Egyptian obese women and might predict the future cardio-metabolic events. Leibniz Research Centre for Working Environment and Human Factors 2017-06-29 /pmc/articles/PMC5579397/ /pubmed/28900377 http://dx.doi.org/10.17179/excli2017-275 Text en Copyright © 2017 Zaki et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Zaki, Moushira
Kamal, Sanaa
Kholousi, Shams
El-Bassyouni, Hala T.
Yousef, Walaa
Reyad, Hanaa
Mohamed, Ramy
Basha, Walaa A.
Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women
title Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women
title_full Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women
title_fullStr Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women
title_full_unstemmed Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women
title_short Serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in Egyptian obese women
title_sort serum soluble receptor of advanced glycation end products and risk of metabolic syndrome in egyptian obese women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579397/
https://www.ncbi.nlm.nih.gov/pubmed/28900377
http://dx.doi.org/10.17179/excli2017-275
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