Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis

The proteasome inhibitor, bortezomib, is ineffective against many solid tumors. Nutlin-3 is a potent antagonist of human homolog of murine double minute 2/p53 interaction exhibiting promising therapeutic anti-cancer activity. In this study, we show that treatment of various p53-defective bortezomib-...

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Detalles Bibliográficos
Autores principales: Lee, Dong Min, Kim, In Young, Seo, Min Ji, Kwon, Mi Ri, Choi, Kyeong Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579507/
https://www.ncbi.nlm.nih.gov/pubmed/28798402
http://dx.doi.org/10.1038/emm.2017.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579507/
https://www.ncbi.nlm.nih.gov/pubmed/28798402
http://dx.doi.org/10.1038/emm.2017.112

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