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Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis
The proteasome inhibitor, bortezomib, is ineffective against many solid tumors. Nutlin-3 is a potent antagonist of human homolog of murine double minute 2/p53 interaction exhibiting promising therapeutic anti-cancer activity. In this study, we show that treatment of various p53-defective bortezomib-...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579507/ https://www.ncbi.nlm.nih.gov/pubmed/28798402 http://dx.doi.org/10.1038/emm.2017.112 |