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The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC...
Autores principales: | Liu, Chun-Yu, Huang, Tzu-Ting, Chu, Pei-Yi, Huang, Chun-Teng, Lee, Chia-Han, Wang, Wan-Lun, Lau, Ka-Yi, Tsai, Wen-Chun, Chao, Tzu-I, Su, Jung-Chen, Chen, Ming-Huang, Shiau, Chung-Wai, Tseng, Ling-Ming, Chen, Kuen-Feng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579508/ https://www.ncbi.nlm.nih.gov/pubmed/28798401 http://dx.doi.org/10.1038/emm.2017.114 |
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