Tandem Palladium and Isothiourea Relay Catalysis: Enantioselective Synthesis of α-Amino Acid Derivatives via Allylic Amination and [2,3]-Sigmatropic Rearrangement

[Image: see text] A tandem relay catalytic protocol using both Pd and isothiourea catalysis has been developed for the enantioselective synthesis of α-amino acid derivatives containing two stereogenic centers from readily accessible N,N-disubstituted glycine aryl esters and allylic phosphates. The o...

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Detalles Bibliográficos
Autores principales: Spoehrle, Stéphanie S. M., West, Thomas H., Taylor, James E., Slawin, Alexandra M. Z., Smith, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579534/
https://www.ncbi.nlm.nih.gov/pubmed/28763205
http://dx.doi.org/10.1021/jacs.7b05619

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