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Conformational Dynamics Modulate Activation of the Ubiquitin Conjugating Enzyme Ube2g2

[Image: see text] The ubiquitin conjugating enzyme Ube2g2 together with its cognate E3 ligase gp78 catalyzes the synthesis of lysine-48 polyubiquitin chains constituting signals for the proteasomal degradation of misfolded proteins in the endoplasmic reticulum. Here, we employ NMR spectroscopy in co...

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Detalles Bibliográficos
Autores principales:	Magala, Pearl, Bocik, William E., Majumdar, Ananya, Tolman, Joel R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579538/ https://www.ncbi.nlm.nih.gov/pubmed/28884161 http://dx.doi.org/10.1021/acsomega.7b00205

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