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Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations

[Image: see text] Computational screening is a method to prioritize small-molecule compounds based on the structural and biochemical attributes built from ligand and target information. Previously, we have developed a scalable virtual screening workflow to identify novel multitarget kinase/bromodoma...

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Detalles Bibliográficos
Autores principales:	Allen, Bryce K., Mehta, Saurabh, Ember, Stuart W. J., Zhu, Jin-Yi, Schönbrunn, Ernst, Ayad, Nagi G., Schürer, Stephan C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579542/ https://www.ncbi.nlm.nih.gov/pubmed/28884163 http://dx.doi.org/10.1021/acsomega.7b00553

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