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Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis

[Image: see text] Enediynes are potent natural product anticancer antibiotics, and are classified as 9- or 10-membered according to the size of their enediyne core carbon skeleton. Both 9- and 10-membered enediyne cores are biosynthesized by the enediyne polyketide synthase (PKSE), thioesterase (TE)...

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Detalles Bibliográficos
Autores principales:	Annaval, Thibault, Rudolf, Jeffrey D., Chang, Chin-Yuan, Lohman, Jeremy R., Kim, Youngchang, Bigelow, Lance, Jedrzejczak, Robert, Babnigg, Gyorgy, Joachimiak, Andrzej, Phillips, George N., Shen, Ben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579567/ https://www.ncbi.nlm.nih.gov/pubmed/28884166 http://dx.doi.org/10.1021/acsomega.7b00933

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