Cargando…
Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients
(1) Background: Lower levels of serum 25-hydroxyvitamin D (25(OH)D) are common in osteoarthritis (OA) patients. However, the effect of vitamin D supplementation on muscle strength and physical performance remains unclear. This study will investigate the effects of vitamin D(2) supplementation on mus...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579593/ https://www.ncbi.nlm.nih.gov/pubmed/28933742 http://dx.doi.org/10.3390/nu9080799 |
_version_ | 1783260737371635712 |
---|---|
author | Manoy, Pacharee Yuktanandana, Pongsak Tanavalee, Aree Anomasiri, Wilai Ngarmukos, Srihatach Tanpowpong, Thanathep Honsawek, Sittisak |
author_facet | Manoy, Pacharee Yuktanandana, Pongsak Tanavalee, Aree Anomasiri, Wilai Ngarmukos, Srihatach Tanpowpong, Thanathep Honsawek, Sittisak |
author_sort | Manoy, Pacharee |
collection | PubMed |
description | (1) Background: Lower levels of serum 25-hydroxyvitamin D (25(OH)D) are common in osteoarthritis (OA) patients. However, the effect of vitamin D supplementation on muscle strength and physical performance remains unclear. This study will investigate the effects of vitamin D(2) supplementation on muscle strength and physical performance in knee OA patients; (2) Methods: One hundred and seventy-five primary knee OA patients with low levels of serum 25(OH)D (<30 ng/mL) received 40,000 IU vitamin D(2) (ergocalciferol) per week for six months. Body composition, muscle strength, physical performance, serum 25(OH)D level, leptin, interlukin-6 (IL-6), parathyroid hormone (PTH), protein carbonyl, and metabolic profile were analyzed; (3) Results: Baseline mean serum 25(OH)D levels in knee OA patients was 20.73 ng/mL. Regarding baseline vitamin D status, 58.90% of patients had vitamin D insufficiency, and 41.10% had vitamin D deficiency. After vitamin D(2) supplementation for six months, mean serum 25(OH)D level was 32.14 ng/mL. For post-supplementation vitamin D status, 57.10% of patients had vitamin D sufficiency and 42.90% had vitamin D insufficiency. From baseline to six months, there was a significant increase in mean serum 25(OH)D level (p < 0.001), while mean LDL cholesterol (p = 0.001), protein carbonyl (p = 0.04), and PTH (p = 0.005) all significantly decreased. Patient quality of life (SF-12) and pain (visual analog scale, VAS) both improved significantly from baseline to the six-month time point (p = 0.005 and p = 0.002, respectively). Knee OA patients demonstrated significant improvement grip strength and physical performance measurements after vitamin D(2) supplementation (p < 0.05); (4) Conclusions: Vitamin D(2) supplementation for six months reduced oxidative protein damage, decreased pain (VAS), improved quality of life, and improved grip strength and physical performance in osteoarthritis patients. |
format | Online Article Text |
id | pubmed-5579593 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55795932017-09-06 Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients Manoy, Pacharee Yuktanandana, Pongsak Tanavalee, Aree Anomasiri, Wilai Ngarmukos, Srihatach Tanpowpong, Thanathep Honsawek, Sittisak Nutrients Article (1) Background: Lower levels of serum 25-hydroxyvitamin D (25(OH)D) are common in osteoarthritis (OA) patients. However, the effect of vitamin D supplementation on muscle strength and physical performance remains unclear. This study will investigate the effects of vitamin D(2) supplementation on muscle strength and physical performance in knee OA patients; (2) Methods: One hundred and seventy-five primary knee OA patients with low levels of serum 25(OH)D (<30 ng/mL) received 40,000 IU vitamin D(2) (ergocalciferol) per week for six months. Body composition, muscle strength, physical performance, serum 25(OH)D level, leptin, interlukin-6 (IL-6), parathyroid hormone (PTH), protein carbonyl, and metabolic profile were analyzed; (3) Results: Baseline mean serum 25(OH)D levels in knee OA patients was 20.73 ng/mL. Regarding baseline vitamin D status, 58.90% of patients had vitamin D insufficiency, and 41.10% had vitamin D deficiency. After vitamin D(2) supplementation for six months, mean serum 25(OH)D level was 32.14 ng/mL. For post-supplementation vitamin D status, 57.10% of patients had vitamin D sufficiency and 42.90% had vitamin D insufficiency. From baseline to six months, there was a significant increase in mean serum 25(OH)D level (p < 0.001), while mean LDL cholesterol (p = 0.001), protein carbonyl (p = 0.04), and PTH (p = 0.005) all significantly decreased. Patient quality of life (SF-12) and pain (visual analog scale, VAS) both improved significantly from baseline to the six-month time point (p = 0.005 and p = 0.002, respectively). Knee OA patients demonstrated significant improvement grip strength and physical performance measurements after vitamin D(2) supplementation (p < 0.05); (4) Conclusions: Vitamin D(2) supplementation for six months reduced oxidative protein damage, decreased pain (VAS), improved quality of life, and improved grip strength and physical performance in osteoarthritis patients. MDPI 2017-07-26 /pmc/articles/PMC5579593/ /pubmed/28933742 http://dx.doi.org/10.3390/nu9080799 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Manoy, Pacharee Yuktanandana, Pongsak Tanavalee, Aree Anomasiri, Wilai Ngarmukos, Srihatach Tanpowpong, Thanathep Honsawek, Sittisak Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients |
title | Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients |
title_full | Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients |
title_fullStr | Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients |
title_full_unstemmed | Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients |
title_short | Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients |
title_sort | vitamin d supplementation improves quality of life and physical performance in osteoarthritis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579593/ https://www.ncbi.nlm.nih.gov/pubmed/28933742 http://dx.doi.org/10.3390/nu9080799 |
work_keys_str_mv | AT manoypacharee vitamindsupplementationimprovesqualityoflifeandphysicalperformanceinosteoarthritispatients AT yuktanandanapongsak vitamindsupplementationimprovesqualityoflifeandphysicalperformanceinosteoarthritispatients AT tanavaleearee vitamindsupplementationimprovesqualityoflifeandphysicalperformanceinosteoarthritispatients AT anomasiriwilai vitamindsupplementationimprovesqualityoflifeandphysicalperformanceinosteoarthritispatients AT ngarmukossrihatach vitamindsupplementationimprovesqualityoflifeandphysicalperformanceinosteoarthritispatients AT tanpowpongthanathep vitamindsupplementationimprovesqualityoflifeandphysicalperformanceinosteoarthritispatients AT honsaweksittisak vitamindsupplementationimprovesqualityoflifeandphysicalperformanceinosteoarthritispatients |