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Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels

Iron supplementation contributes an effort to improving iron status among athletes, but it does not always prevent iron deficiency. In the present study, we explored the effect of three consecutive days of endurance training (twice daily) on the hepcidin-25 (hepcidin) level. The effect of iron suppl...

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Autores principales: Ishibashi, Aya, Maeda, Naho, Kamei, Akiko, Goto, Kazushige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579614/
https://www.ncbi.nlm.nih.gov/pubmed/28758951
http://dx.doi.org/10.3390/nu9080820
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author Ishibashi, Aya
Maeda, Naho
Kamei, Akiko
Goto, Kazushige
author_facet Ishibashi, Aya
Maeda, Naho
Kamei, Akiko
Goto, Kazushige
author_sort Ishibashi, Aya
collection PubMed
description Iron supplementation contributes an effort to improving iron status among athletes, but it does not always prevent iron deficiency. In the present study, we explored the effect of three consecutive days of endurance training (twice daily) on the hepcidin-25 (hepcidin) level. The effect of iron supplementation during this period was also determined. Fourteen male endurance athletes were enrolled and randomly assigned to either an iron-treated condition (Fe condition, n = 7) or a placebo condition (Control condition; CON, n = 7). They engaged in two 75-min sessions of treadmill running at 75% of maximal oxygen uptake on three consecutive days (days 1–3). The Fe condition took 12 mg of iron twice daily (24 mg/day), and the CON condition did not. On day 1, both conditions exhibited significant increases in serum hepcidin and plasma interleukin-6 levels after exercise (p < 0.05). In the CON condition, the hepcidin level did not change significantly throughout the training period. However, in the Fe condition, the serum hepcidin level on day 4 was significantly higher than that of the CON condition (p < 0.05). In conclusion, the hepcidin level was significantly elevated following three consecutive days of endurance training when moderate doses of iron were taken.
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spelling pubmed-55796142017-09-06 Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels Ishibashi, Aya Maeda, Naho Kamei, Akiko Goto, Kazushige Nutrients Article Iron supplementation contributes an effort to improving iron status among athletes, but it does not always prevent iron deficiency. In the present study, we explored the effect of three consecutive days of endurance training (twice daily) on the hepcidin-25 (hepcidin) level. The effect of iron supplementation during this period was also determined. Fourteen male endurance athletes were enrolled and randomly assigned to either an iron-treated condition (Fe condition, n = 7) or a placebo condition (Control condition; CON, n = 7). They engaged in two 75-min sessions of treadmill running at 75% of maximal oxygen uptake on three consecutive days (days 1–3). The Fe condition took 12 mg of iron twice daily (24 mg/day), and the CON condition did not. On day 1, both conditions exhibited significant increases in serum hepcidin and plasma interleukin-6 levels after exercise (p < 0.05). In the CON condition, the hepcidin level did not change significantly throughout the training period. However, in the Fe condition, the serum hepcidin level on day 4 was significantly higher than that of the CON condition (p < 0.05). In conclusion, the hepcidin level was significantly elevated following three consecutive days of endurance training when moderate doses of iron were taken. MDPI 2017-07-30 /pmc/articles/PMC5579614/ /pubmed/28758951 http://dx.doi.org/10.3390/nu9080820 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ishibashi, Aya
Maeda, Naho
Kamei, Akiko
Goto, Kazushige
Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels
title Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels
title_full Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels
title_fullStr Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels
title_full_unstemmed Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels
title_short Iron Supplementation during Three Consecutive Days of Endurance Training Augmented Hepcidin Levels
title_sort iron supplementation during three consecutive days of endurance training augmented hepcidin levels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579614/
https://www.ncbi.nlm.nih.gov/pubmed/28758951
http://dx.doi.org/10.3390/nu9080820
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