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Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications

To follow up the restenosis in arteries stented during an angioplasty is an important current clinical problem. A new approach to monitor the growth of neointimal tissue inside the stent is proposed on the basis of electrical impedance spectroscopy (EIS) sensors and the oscillation-based test (OBT)...

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Autores principales: Rivas-Marchena, David, Olmo, Alberto, Miguel, José A., Martínez, Mar, Huertas, Gloria, Yúfera, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579752/
https://www.ncbi.nlm.nih.gov/pubmed/28788093
http://dx.doi.org/10.3390/s17081737
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author Rivas-Marchena, David
Olmo, Alberto
Miguel, José A.
Martínez, Mar
Huertas, Gloria
Yúfera, Alberto
author_facet Rivas-Marchena, David
Olmo, Alberto
Miguel, José A.
Martínez, Mar
Huertas, Gloria
Yúfera, Alberto
author_sort Rivas-Marchena, David
collection PubMed
description To follow up the restenosis in arteries stented during an angioplasty is an important current clinical problem. A new approach to monitor the growth of neointimal tissue inside the stent is proposed on the basis of electrical impedance spectroscopy (EIS) sensors and the oscillation-based test (OBT) circuit technique. A mathematical model was developed to analytically describe the histological composition of the neointima, employing its conductivity and permittivity data. The bioimpedance model was validated against a finite element analysis (FEA) using COMSOL Multiphysics software. A satisfactory correlation between the analytical model and FEA simulation was achieved in most cases, detecting some deviations introduced by the thin “double layer” that separates the neointima and the blood. It is hereby shown how to apply conformal transformations to obtain bioimpedance electrical models for stack-layered tissues over coplanar electrodes. Particularly, this can be applied to characterize the neointima in real-time. This technique is either suitable as a main mechanism for restenosis follow-up or it can be combined with proposed intelligent stents for blood pressure measurements to auto-calibrate the sensibility loss caused by the adherence of the tissue on the micro-electro-mechanical sensors (MEMSs).
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spelling pubmed-55797522017-09-06 Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications Rivas-Marchena, David Olmo, Alberto Miguel, José A. Martínez, Mar Huertas, Gloria Yúfera, Alberto Sensors (Basel) Article To follow up the restenosis in arteries stented during an angioplasty is an important current clinical problem. A new approach to monitor the growth of neointimal tissue inside the stent is proposed on the basis of electrical impedance spectroscopy (EIS) sensors and the oscillation-based test (OBT) circuit technique. A mathematical model was developed to analytically describe the histological composition of the neointima, employing its conductivity and permittivity data. The bioimpedance model was validated against a finite element analysis (FEA) using COMSOL Multiphysics software. A satisfactory correlation between the analytical model and FEA simulation was achieved in most cases, detecting some deviations introduced by the thin “double layer” that separates the neointima and the blood. It is hereby shown how to apply conformal transformations to obtain bioimpedance electrical models for stack-layered tissues over coplanar electrodes. Particularly, this can be applied to characterize the neointima in real-time. This technique is either suitable as a main mechanism for restenosis follow-up or it can be combined with proposed intelligent stents for blood pressure measurements to auto-calibrate the sensibility loss caused by the adherence of the tissue on the micro-electro-mechanical sensors (MEMSs). MDPI 2017-07-28 /pmc/articles/PMC5579752/ /pubmed/28788093 http://dx.doi.org/10.3390/s17081737 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rivas-Marchena, David
Olmo, Alberto
Miguel, José A.
Martínez, Mar
Huertas, Gloria
Yúfera, Alberto
Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications
title Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications
title_full Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications
title_fullStr Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications
title_full_unstemmed Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications
title_short Real-Time Electrical Bioimpedance Characterization of Neointimal Tissue for Stent Applications
title_sort real-time electrical bioimpedance characterization of neointimal tissue for stent applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579752/
https://www.ncbi.nlm.nih.gov/pubmed/28788093
http://dx.doi.org/10.3390/s17081737
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