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Cardiovascular Events in Hemodialysis Patients: Challenging against Vascular Calcification

Particularly in patients with hemodialysis, cardiovascular mortality rate is extremely high. Polyvascular diseases develop at an early stage of chronic kidney disease (CKD). Pathophysiology includes insulin resistance and/or imbalance between nitric oxide (NO) and endothelin bioavailability as well...

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Detalles Bibliográficos
Autor principal: Kobayashi, Shuzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579802/
https://www.ncbi.nlm.nih.gov/pubmed/29034013
http://dx.doi.org/10.3400/avd.ra.17-00006
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author Kobayashi, Shuzo
author_facet Kobayashi, Shuzo
author_sort Kobayashi, Shuzo
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description Particularly in patients with hemodialysis, cardiovascular mortality rate is extremely high. Polyvascular diseases develop at an early stage of chronic kidney disease (CKD). Pathophysiology includes insulin resistance and/or imbalance between nitric oxide (NO) and endothelin bioavailability as well as oxidative stress. The understanding in pathophysiology of vascular calcification and strategic treatment is a critical issue to achieve favorable outcome for the patients with CKD. In this article, we aim to review the cardiovascular disease for the patients with CKD with a particular emphasis on the clinical aspects of polyvascular disease. Finally, we address to detect microcirculatory impairment and eradicate vascular calcification as early as possible prior to renal replacement therapy. (This is a translation of Jpn J Vasc Surg 2016; 25: 359–365.)
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spelling pubmed-55798022017-10-13 Cardiovascular Events in Hemodialysis Patients: Challenging against Vascular Calcification Kobayashi, Shuzo Ann Vasc Dis Review Article Particularly in patients with hemodialysis, cardiovascular mortality rate is extremely high. Polyvascular diseases develop at an early stage of chronic kidney disease (CKD). Pathophysiology includes insulin resistance and/or imbalance between nitric oxide (NO) and endothelin bioavailability as well as oxidative stress. The understanding in pathophysiology of vascular calcification and strategic treatment is a critical issue to achieve favorable outcome for the patients with CKD. In this article, we aim to review the cardiovascular disease for the patients with CKD with a particular emphasis on the clinical aspects of polyvascular disease. Finally, we address to detect microcirculatory impairment and eradicate vascular calcification as early as possible prior to renal replacement therapy. (This is a translation of Jpn J Vasc Surg 2016; 25: 359–365.) Japanese College of Angiology / The Japanese Society for Vascular Surgery / Japanese Society of Phlebology 2017-03-24 2017-03-31 /pmc/articles/PMC5579802/ /pubmed/29034013 http://dx.doi.org/10.3400/avd.ra.17-00006 Text en Copyright © 2017 Annals of Vascular Diseases http://creativecommons.org/licenses/by-nc-sa/4.0/ This article is distributed under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided the credit of the original work, a link to the license, and indication of any change are properly given, and the original work is not used for commercial purposes. Remixed or transformed contributions must be distributed under the same license as the original.
spellingShingle Review Article
Kobayashi, Shuzo
Cardiovascular Events in Hemodialysis Patients: Challenging against Vascular Calcification
title Cardiovascular Events in Hemodialysis Patients: Challenging against Vascular Calcification
title_full Cardiovascular Events in Hemodialysis Patients: Challenging against Vascular Calcification
title_fullStr Cardiovascular Events in Hemodialysis Patients: Challenging against Vascular Calcification
title_full_unstemmed Cardiovascular Events in Hemodialysis Patients: Challenging against Vascular Calcification
title_short Cardiovascular Events in Hemodialysis Patients: Challenging against Vascular Calcification
title_sort cardiovascular events in hemodialysis patients: challenging against vascular calcification
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579802/
https://www.ncbi.nlm.nih.gov/pubmed/29034013
http://dx.doi.org/10.3400/avd.ra.17-00006
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