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Triple synchronous primary lung cancer: a case report and review of the literature

BACKGROUND: Multiple primary lung cancer may present in synchronous or metachronous form. Synchronous multiple primary lung cancer is defined as multiple lung lesions that develop at the same time, whereas metachronous multiple primary lung cancer describes multiple lung lesions that develop at diff...

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Autores principales: Kashif, Muhammad, Ayyadurai, Puvanalingam, Thanha, Luong, Khaja, Misbahuddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579871/
https://www.ncbi.nlm.nih.gov/pubmed/28859661
http://dx.doi.org/10.1186/s13256-017-1410-4
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author Kashif, Muhammad
Ayyadurai, Puvanalingam
Thanha, Luong
Khaja, Misbahuddin
author_facet Kashif, Muhammad
Ayyadurai, Puvanalingam
Thanha, Luong
Khaja, Misbahuddin
author_sort Kashif, Muhammad
collection PubMed
description BACKGROUND: Multiple primary lung cancer may present in synchronous or metachronous form. Synchronous multiple primary lung cancer is defined as multiple lung lesions that develop at the same time, whereas metachronous multiple primary lung cancer describes multiple lung lesions that develop at different times, typically following treatment of the primary lung cancer. Patients with previously treated lung cancer are at risk for developing metachronous lung cancer, but with the success of computed tomography and positron emission tomography, the ability to detect both synchronous and metachronous lung cancer has increased. CASE PRESENTATION: We present a case of a 63-year-old Hispanic man who came to our hospital for evaluation of chest pain, dry cough, and weight loss. He had recently been diagnosed with adenocarcinoma in the right upper lobe, with a poorly differentiated carcinoma favoring squamous cell cancer based on bronchoalveolar lavage of the right lower lobe for which treatment was started. Later, bronchoscopy incidentally revealed the patient to have an endobronchial lesion that turned out to be mixed small and large cell neuroendocrine lung cancer. Our patient had triple synchronous primary lung cancers that histologically were variant primary cancers. CONCLUSIONS: Triple synchronous primary lung cancer management continues to be a challenge. Our patient’s case suggests that multiple primary lung cancers may still occur at a greater rate than can be detected by high-resolution computed tomography.
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spelling pubmed-55798712017-09-05 Triple synchronous primary lung cancer: a case report and review of the literature Kashif, Muhammad Ayyadurai, Puvanalingam Thanha, Luong Khaja, Misbahuddin J Med Case Rep Case Report BACKGROUND: Multiple primary lung cancer may present in synchronous or metachronous form. Synchronous multiple primary lung cancer is defined as multiple lung lesions that develop at the same time, whereas metachronous multiple primary lung cancer describes multiple lung lesions that develop at different times, typically following treatment of the primary lung cancer. Patients with previously treated lung cancer are at risk for developing metachronous lung cancer, but with the success of computed tomography and positron emission tomography, the ability to detect both synchronous and metachronous lung cancer has increased. CASE PRESENTATION: We present a case of a 63-year-old Hispanic man who came to our hospital for evaluation of chest pain, dry cough, and weight loss. He had recently been diagnosed with adenocarcinoma in the right upper lobe, with a poorly differentiated carcinoma favoring squamous cell cancer based on bronchoalveolar lavage of the right lower lobe for which treatment was started. Later, bronchoscopy incidentally revealed the patient to have an endobronchial lesion that turned out to be mixed small and large cell neuroendocrine lung cancer. Our patient had triple synchronous primary lung cancers that histologically were variant primary cancers. CONCLUSIONS: Triple synchronous primary lung cancer management continues to be a challenge. Our patient’s case suggests that multiple primary lung cancers may still occur at a greater rate than can be detected by high-resolution computed tomography. BioMed Central 2017-09-01 /pmc/articles/PMC5579871/ /pubmed/28859661 http://dx.doi.org/10.1186/s13256-017-1410-4 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Kashif, Muhammad
Ayyadurai, Puvanalingam
Thanha, Luong
Khaja, Misbahuddin
Triple synchronous primary lung cancer: a case report and review of the literature
title Triple synchronous primary lung cancer: a case report and review of the literature
title_full Triple synchronous primary lung cancer: a case report and review of the literature
title_fullStr Triple synchronous primary lung cancer: a case report and review of the literature
title_full_unstemmed Triple synchronous primary lung cancer: a case report and review of the literature
title_short Triple synchronous primary lung cancer: a case report and review of the literature
title_sort triple synchronous primary lung cancer: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579871/
https://www.ncbi.nlm.nih.gov/pubmed/28859661
http://dx.doi.org/10.1186/s13256-017-1410-4
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