Endoscopic Mucosal Resection of Jejunal Polyps using Double-Balloon Enteroscopy

BACKGROUND: There are only two single case reports describing double-balloon enteroscopy (DBE)-assisted endoscopic mucosal resection (EMR) of the jejunum. The aim of this case series was to evaluate the feasibility and utility of DBE-assisted EMR in patients with familial and non-familial jejunal polyps. PATIENTS AND METHODS: Observational, open-label, retrospective, single-arm case series in two hospitals. RESULTS: Eight patients underwent DBE assisted jejunal EMR. Median age of patients was 42 years (range 24–62 years), male: female ratio 1.5:1. DBE was done through the antegrade (i.e. oral) route in all patients. Four patients had FAP; two had Peutz-Jeghers syndrome, one had a sporadic adenoma and one had a bleeding jejunal polyp, which on histological examination turned out to be lipoma. 3/8 underwent piece-meal EMR. No immediate adverse events occurred. CONCLUSIONS: This is the first case series presenting the technical details, feasibility and outcomes of EMR of the small bowel. EMR of the jejunum is feasible and safe during DBE.