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Detection of Four Distinct Volatile Indicators of Colorectal Cancer using Functionalized Titania Nanotubular Arrays

Screening of colorectal cancer is crucial for early stage diagnosis and treatment. Detection of volatile organic compounds (VOCs) of the metabolome present in exhaled breath is a promising approach to screen colorectal cancer (CRC). Various forms of volatile organic compounds (VOCs) that show the de...

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Autores principales: Bhattacharyya, Dhiman, Kumar, Pankaj, Mohanty, Swomitra K., Smith, York R., Misra, Mano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580033/
https://www.ncbi.nlm.nih.gov/pubmed/28777343
http://dx.doi.org/10.3390/s17081795
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author Bhattacharyya, Dhiman
Kumar, Pankaj
Mohanty, Swomitra K.
Smith, York R.
Misra, Mano
author_facet Bhattacharyya, Dhiman
Kumar, Pankaj
Mohanty, Swomitra K.
Smith, York R.
Misra, Mano
author_sort Bhattacharyya, Dhiman
collection PubMed
description Screening of colorectal cancer is crucial for early stage diagnosis and treatment. Detection of volatile organic compounds (VOCs) of the metabolome present in exhaled breath is a promising approach to screen colorectal cancer (CRC). Various forms of volatile organic compounds (VOCs) that show the definitive signature for the different diseases including cancers are present in exhale breathe. Among all the reported CRC VOCs, cyclohexane, methylcyclohexane, 1,3-dimethyl- benzene and decanal are identified as the prominent ones that can be used as the signature for CRC screening. In the present investigation, detection of the four prominent VOCs related to CRC is explored using functionalized titania nanotubular arrays (TNAs)-based sensor. These signature biomarkers are shown to be detected using nickel-functionalized TNA as an electrochemical sensor. The sensing mechanism is based on the electrochemical interaction of nickel-functionalized nanotubes with signature biomarkers. A detailed mechanism of the sensor response is also presented.
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spelling pubmed-55800332017-09-06 Detection of Four Distinct Volatile Indicators of Colorectal Cancer using Functionalized Titania Nanotubular Arrays Bhattacharyya, Dhiman Kumar, Pankaj Mohanty, Swomitra K. Smith, York R. Misra, Mano Sensors (Basel) Article Screening of colorectal cancer is crucial for early stage diagnosis and treatment. Detection of volatile organic compounds (VOCs) of the metabolome present in exhaled breath is a promising approach to screen colorectal cancer (CRC). Various forms of volatile organic compounds (VOCs) that show the definitive signature for the different diseases including cancers are present in exhale breathe. Among all the reported CRC VOCs, cyclohexane, methylcyclohexane, 1,3-dimethyl- benzene and decanal are identified as the prominent ones that can be used as the signature for CRC screening. In the present investigation, detection of the four prominent VOCs related to CRC is explored using functionalized titania nanotubular arrays (TNAs)-based sensor. These signature biomarkers are shown to be detected using nickel-functionalized TNA as an electrochemical sensor. The sensing mechanism is based on the electrochemical interaction of nickel-functionalized nanotubes with signature biomarkers. A detailed mechanism of the sensor response is also presented. MDPI 2017-08-04 /pmc/articles/PMC5580033/ /pubmed/28777343 http://dx.doi.org/10.3390/s17081795 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bhattacharyya, Dhiman
Kumar, Pankaj
Mohanty, Swomitra K.
Smith, York R.
Misra, Mano
Detection of Four Distinct Volatile Indicators of Colorectal Cancer using Functionalized Titania Nanotubular Arrays
title Detection of Four Distinct Volatile Indicators of Colorectal Cancer using Functionalized Titania Nanotubular Arrays
title_full Detection of Four Distinct Volatile Indicators of Colorectal Cancer using Functionalized Titania Nanotubular Arrays
title_fullStr Detection of Four Distinct Volatile Indicators of Colorectal Cancer using Functionalized Titania Nanotubular Arrays
title_full_unstemmed Detection of Four Distinct Volatile Indicators of Colorectal Cancer using Functionalized Titania Nanotubular Arrays
title_short Detection of Four Distinct Volatile Indicators of Colorectal Cancer using Functionalized Titania Nanotubular Arrays
title_sort detection of four distinct volatile indicators of colorectal cancer using functionalized titania nanotubular arrays
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580033/
https://www.ncbi.nlm.nih.gov/pubmed/28777343
http://dx.doi.org/10.3390/s17081795
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