Next-generation disulfide stapling: reduction and functional re-bridging all in one

Herein we present a significant step towards next-generation disulfide stapling reagents. A novel class of reagent has been designed to effect both disulfide reduction and functional re-bridging. The strategy has been applied to great success across various peptides and proteins. Moreover, applicati...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Maximillian T. W., Maruani, Antoine, Baker, James R., Caddick, Stephen, Chudasama, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580075/
https://www.ncbi.nlm.nih.gov/pubmed/28966772
http://dx.doi.org/10.1039/c5sc02666k
_version_ 1783260841085239296
author Lee, Maximillian T. W.
Maruani, Antoine
Baker, James R.
Caddick, Stephen
Chudasama, Vijay
author_facet Lee, Maximillian T. W.
Maruani, Antoine
Baker, James R.
Caddick, Stephen
Chudasama, Vijay
author_sort Lee, Maximillian T. W.
collection PubMed
description Herein we present a significant step towards next-generation disulfide stapling reagents. A novel class of reagent has been designed to effect both disulfide reduction and functional re-bridging. The strategy has been applied to great success across various peptides and proteins. Moreover, application to a multi-disulfide system resulted in functional re-bridging without disulfide scrambling.
format Online
Article
Text
id pubmed-5580075
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Royal Society of Chemistry
record_format MEDLINE/PubMed
spelling pubmed-55800752017-09-29 Next-generation disulfide stapling: reduction and functional re-bridging all in one Lee, Maximillian T. W. Maruani, Antoine Baker, James R. Caddick, Stephen Chudasama, Vijay Chem Sci Chemistry Herein we present a significant step towards next-generation disulfide stapling reagents. A novel class of reagent has been designed to effect both disulfide reduction and functional re-bridging. The strategy has been applied to great success across various peptides and proteins. Moreover, application to a multi-disulfide system resulted in functional re-bridging without disulfide scrambling. Royal Society of Chemistry 2016-01-01 2015-09-15 /pmc/articles/PMC5580075/ /pubmed/28966772 http://dx.doi.org/10.1039/c5sc02666k Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Lee, Maximillian T. W.
Maruani, Antoine
Baker, James R.
Caddick, Stephen
Chudasama, Vijay
Next-generation disulfide stapling: reduction and functional re-bridging all in one
title Next-generation disulfide stapling: reduction and functional re-bridging all in one
title_full Next-generation disulfide stapling: reduction and functional re-bridging all in one
title_fullStr Next-generation disulfide stapling: reduction and functional re-bridging all in one
title_full_unstemmed Next-generation disulfide stapling: reduction and functional re-bridging all in one
title_short Next-generation disulfide stapling: reduction and functional re-bridging all in one
title_sort next-generation disulfide stapling: reduction and functional re-bridging all in one
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580075/
https://www.ncbi.nlm.nih.gov/pubmed/28966772
http://dx.doi.org/10.1039/c5sc02666k
work_keys_str_mv AT leemaximilliantw nextgenerationdisulfidestaplingreductionandfunctionalrebridgingallinone
AT maruaniantoine nextgenerationdisulfidestaplingreductionandfunctionalrebridgingallinone
AT bakerjamesr nextgenerationdisulfidestaplingreductionandfunctionalrebridgingallinone
AT caddickstephen nextgenerationdisulfidestaplingreductionandfunctionalrebridgingallinone
AT chudasamavijay nextgenerationdisulfidestaplingreductionandfunctionalrebridgingallinone

Ejemplares similares