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Imagiological Diagnosis of Gastrointestinal Diseases – Diagnostic Criteria of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the leading causes of neoplastic morbidity and mortality worldwide, and despite recent treatment advances, the prognosis remains dismal, with a 5-year mortality rate of 85%. The surveillance and timely diagnosis is therefore of crucial importance in order to...

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Autores principales: Boal Carvalho, Pedro, Pereira, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Karger Publishers 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580142/
https://www.ncbi.nlm.nih.gov/pubmed/28868398
http://dx.doi.org/10.1016/j.jpge.2015.04.002
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author Boal Carvalho, Pedro
Pereira, Eduardo
author_facet Boal Carvalho, Pedro
Pereira, Eduardo
author_sort Boal Carvalho, Pedro
collection PubMed
description Hepatocellular carcinoma (HCC) is one of the leading causes of neoplastic morbidity and mortality worldwide, and despite recent treatment advances, the prognosis remains dismal, with a 5-year mortality rate of 85%. The surveillance and timely diagnosis is therefore of crucial importance in order to improve survival rates and alleviate the health burden imposed by the HCC. Previously, HCC diagnosis warranted liver biopsy, an invasive process with limited diagnostic accuracy. In the past 15 years, HCC diagnosis based solely on imaging criteria was accepted by all the major national and international guidelines, and is now widely employed across the globe. Current European guidelines for the HCC diagnosis support the use of both dynamic contrasted computer tomography as well as magnetic resonance imaging for the non-invasive diagnosis of HCC for nodules >1 cm in a cirrhotic liver. The non-invasive diagnosis of HCC depends on radiological hallmarks, such as homogeneous contrast uptake during the arterial phase and wash-out during the venous and late phases, but while such tumoral behaviour is frequent in nodules >2 cm, high-end equipment and superior expertise is often needed for the correct diagnosis of early HCC. Nevertheless, the accuracy of imaging techniques for the diagnosis of HCC is permanently improving, and supports the progressively reduced need for liver biopsy during liver nodule workout in a cirrhotic liver.
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spelling pubmed-55801422017-09-01 Imagiological Diagnosis of Gastrointestinal Diseases – Diagnostic Criteria of Hepatocellular Carcinoma Boal Carvalho, Pedro Pereira, Eduardo GE Port J Gastroenterol Review Article Hepatocellular carcinoma (HCC) is one of the leading causes of neoplastic morbidity and mortality worldwide, and despite recent treatment advances, the prognosis remains dismal, with a 5-year mortality rate of 85%. The surveillance and timely diagnosis is therefore of crucial importance in order to improve survival rates and alleviate the health burden imposed by the HCC. Previously, HCC diagnosis warranted liver biopsy, an invasive process with limited diagnostic accuracy. In the past 15 years, HCC diagnosis based solely on imaging criteria was accepted by all the major national and international guidelines, and is now widely employed across the globe. Current European guidelines for the HCC diagnosis support the use of both dynamic contrasted computer tomography as well as magnetic resonance imaging for the non-invasive diagnosis of HCC for nodules >1 cm in a cirrhotic liver. The non-invasive diagnosis of HCC depends on radiological hallmarks, such as homogeneous contrast uptake during the arterial phase and wash-out during the venous and late phases, but while such tumoral behaviour is frequent in nodules >2 cm, high-end equipment and superior expertise is often needed for the correct diagnosis of early HCC. Nevertheless, the accuracy of imaging techniques for the diagnosis of HCC is permanently improving, and supports the progressively reduced need for liver biopsy during liver nodule workout in a cirrhotic liver. Karger Publishers 2015-05-11 /pmc/articles/PMC5580142/ /pubmed/28868398 http://dx.doi.org/10.1016/j.jpge.2015.04.002 Text en © 2015 Sociedade Portuguesa de Gastrenterologia. Published by Elsevier España, S.L.U. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Boal Carvalho, Pedro
Pereira, Eduardo
Imagiological Diagnosis of Gastrointestinal Diseases – Diagnostic Criteria of Hepatocellular Carcinoma
title Imagiological Diagnosis of Gastrointestinal Diseases – Diagnostic Criteria of Hepatocellular Carcinoma
title_full Imagiological Diagnosis of Gastrointestinal Diseases – Diagnostic Criteria of Hepatocellular Carcinoma
title_fullStr Imagiological Diagnosis of Gastrointestinal Diseases – Diagnostic Criteria of Hepatocellular Carcinoma
title_full_unstemmed Imagiological Diagnosis of Gastrointestinal Diseases – Diagnostic Criteria of Hepatocellular Carcinoma
title_short Imagiological Diagnosis of Gastrointestinal Diseases – Diagnostic Criteria of Hepatocellular Carcinoma
title_sort imagiological diagnosis of gastrointestinal diseases – diagnostic criteria of hepatocellular carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580142/
https://www.ncbi.nlm.nih.gov/pubmed/28868398
http://dx.doi.org/10.1016/j.jpge.2015.04.002
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