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Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization

BACKGROUND: China has undergone rapid urbanization in the past three decades. We aimed to report blood lead level (B-Pb) in the most rapidly urbanized Yangtze River Delta Region of China, and explore the association B-Pb and non-alcoholic fatty liver disease (NAFLD). METHODS: Our data source was the...

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Autores principales: Zhai, Hualing, Chen, Chi, Wang, Ningjian, Chen, Yi, Nie, Xiaomin, Han, Bing, Li, Qin, Xia, Fangzhen, Lu, Yingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580229/
https://www.ncbi.nlm.nih.gov/pubmed/28859656
http://dx.doi.org/10.1186/s12940-017-0304-7
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author Zhai, Hualing
Chen, Chi
Wang, Ningjian
Chen, Yi
Nie, Xiaomin
Han, Bing
Li, Qin
Xia, Fangzhen
Lu, Yingli
author_facet Zhai, Hualing
Chen, Chi
Wang, Ningjian
Chen, Yi
Nie, Xiaomin
Han, Bing
Li, Qin
Xia, Fangzhen
Lu, Yingli
author_sort Zhai, Hualing
collection PubMed
description BACKGROUND: China has undergone rapid urbanization in the past three decades. We aimed to report blood lead level (B-Pb) in the most rapidly urbanized Yangtze River Delta Region of China, and explore the association B-Pb and non-alcoholic fatty liver disease (NAFLD). METHODS: Our data source was the SPECT-China study. We enrolled 2011 subjects from 6 villages in the Yangtze River Delta Region. Lead was measured by atomic absorption spectrometry. According to abdominal ultrasound, residents were divided into normal and NAFLD groups. RESULTS: In total, 824 (41.0%) were diagnosed with NAFLD. Medians (interquartile range) of B-Pb were 5.29 μg/dL (3.60–7.28) [0.25 μmol/L (0.17–0.35)] for men and 4.49 μg/dL (2.97–6.59) [0.22 μmol/L (0.14–0.32)] for women. In both genders, the NAFLD group had significantly greater B-Pb than normal group (both P < 0.001). The prevalence of NAFLD significantly increased with increasing B-Pb quartiles in men (P for trend = 0.032) and women (P for trend = 0.001). Residents in Shanghai had significantly greater B-Pb (P < 0.001) and a higher prevalence of NAFLD (P < 0.001). Compared with women in the lowest quartile of BLL, OR of NAFLD in women in the highest quartile was 1.613 (95%CI 1.082–2.405) (P for trend = 0.019) after multivariable adjustment. In men, this association showed marginal significance (OR 2.168, 95%CI 0.989–4.750, P for trend = 0.063). CONCLUSION: B-Pb in Chinese residents in the Yangtze River Delta Region were much higher than in developed countries. Elevated B-Pb was associated with an increased risk of NAFLD, especially in women. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12940-017-0304-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-55802292017-09-07 Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization Zhai, Hualing Chen, Chi Wang, Ningjian Chen, Yi Nie, Xiaomin Han, Bing Li, Qin Xia, Fangzhen Lu, Yingli Environ Health Research BACKGROUND: China has undergone rapid urbanization in the past three decades. We aimed to report blood lead level (B-Pb) in the most rapidly urbanized Yangtze River Delta Region of China, and explore the association B-Pb and non-alcoholic fatty liver disease (NAFLD). METHODS: Our data source was the SPECT-China study. We enrolled 2011 subjects from 6 villages in the Yangtze River Delta Region. Lead was measured by atomic absorption spectrometry. According to abdominal ultrasound, residents were divided into normal and NAFLD groups. RESULTS: In total, 824 (41.0%) were diagnosed with NAFLD. Medians (interquartile range) of B-Pb were 5.29 μg/dL (3.60–7.28) [0.25 μmol/L (0.17–0.35)] for men and 4.49 μg/dL (2.97–6.59) [0.22 μmol/L (0.14–0.32)] for women. In both genders, the NAFLD group had significantly greater B-Pb than normal group (both P < 0.001). The prevalence of NAFLD significantly increased with increasing B-Pb quartiles in men (P for trend = 0.032) and women (P for trend = 0.001). Residents in Shanghai had significantly greater B-Pb (P < 0.001) and a higher prevalence of NAFLD (P < 0.001). Compared with women in the lowest quartile of BLL, OR of NAFLD in women in the highest quartile was 1.613 (95%CI 1.082–2.405) (P for trend = 0.019) after multivariable adjustment. In men, this association showed marginal significance (OR 2.168, 95%CI 0.989–4.750, P for trend = 0.063). CONCLUSION: B-Pb in Chinese residents in the Yangtze River Delta Region were much higher than in developed countries. Elevated B-Pb was associated with an increased risk of NAFLD, especially in women. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12940-017-0304-7) contains supplementary material, which is available to authorized users. BioMed Central 2017-08-31 /pmc/articles/PMC5580229/ /pubmed/28859656 http://dx.doi.org/10.1186/s12940-017-0304-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Zhai, Hualing
Chen, Chi
Wang, Ningjian
Chen, Yi
Nie, Xiaomin
Han, Bing
Li, Qin
Xia, Fangzhen
Lu, Yingli
Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization
title Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization
title_full Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization
title_fullStr Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization
title_full_unstemmed Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization
title_short Blood lead level is associated with non-alcoholic fatty liver disease in the Yangtze River Delta region of China in the context of rapid urbanization
title_sort blood lead level is associated with non-alcoholic fatty liver disease in the yangtze river delta region of china in the context of rapid urbanization
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580229/
https://www.ncbi.nlm.nih.gov/pubmed/28859656
http://dx.doi.org/10.1186/s12940-017-0304-7
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