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A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA
BACKGROUND: Formalin fixed paraffin embedded (FFPE) tumor samples are a major source of DNA from patients in cancer research. However, FFPE is a challenging material to work with due to macromolecular fragmentation and nucleic acid crosslinking. FFPE tissue particularly possesses challenges for meth...
Autores principales: | Ludgate, Jackie L., Wright, James, Stockwell, Peter A., Morison, Ian M., Eccles, Michael R., Chatterjee, Aniruddha |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580311/ https://www.ncbi.nlm.nih.gov/pubmed/28859641 http://dx.doi.org/10.1186/s12920-017-0290-1 |
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