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Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency

BACKGROUND: Leptin has a strong relation to important traits in animal production, such as carcass composition, feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus. In this study, circulating leptin and its gene expression in muscle were e...

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Autores principales: Mota, Lúcio Flávio Macedo, Bonafé, Cristina Moreira, Alexandre, Pâmela Almeida, Santana, Miguel Henrique, Novais, Francisco José, Toriyama, Erika, Pires, Aldrin Vieira, da Luz Silva, Saulo, Leme, Paulo Roberto, Ferraz, José Bento Sterman, Fukumasu, Heidge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580337/
https://www.ncbi.nlm.nih.gov/pubmed/28883916
http://dx.doi.org/10.1186/s40104-017-0203-3
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author Mota, Lúcio Flávio Macedo
Bonafé, Cristina Moreira
Alexandre, Pâmela Almeida
Santana, Miguel Henrique
Novais, Francisco José
Toriyama, Erika
Pires, Aldrin Vieira
da Luz Silva, Saulo
Leme, Paulo Roberto
Ferraz, José Bento Sterman
Fukumasu, Heidge
author_facet Mota, Lúcio Flávio Macedo
Bonafé, Cristina Moreira
Alexandre, Pâmela Almeida
Santana, Miguel Henrique
Novais, Francisco José
Toriyama, Erika
Pires, Aldrin Vieira
da Luz Silva, Saulo
Leme, Paulo Roberto
Ferraz, José Bento Sterman
Fukumasu, Heidge
author_sort Mota, Lúcio Flávio Macedo
collection PubMed
description BACKGROUND: Leptin has a strong relation to important traits in animal production, such as carcass composition, feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus. In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake (DMI) and average daily gain (ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake (RFI) and select 20 animals for the high feed efficient (LRFI) and 20 for the low feed efficient (HRFI) groups. Blood samples were collected on d 56 and at slaughter (80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels. RESULTS: DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness, as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter (P = 0.0049). Gene expression of leptin were greater in LRFI animals (P = 0.0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression. CONCLUSION: These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake.
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spelling pubmed-55803372017-09-07 Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency Mota, Lúcio Flávio Macedo Bonafé, Cristina Moreira Alexandre, Pâmela Almeida Santana, Miguel Henrique Novais, Francisco José Toriyama, Erika Pires, Aldrin Vieira da Luz Silva, Saulo Leme, Paulo Roberto Ferraz, José Bento Sterman Fukumasu, Heidge J Anim Sci Biotechnol Research BACKGROUND: Leptin has a strong relation to important traits in animal production, such as carcass composition, feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus. In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake (DMI) and average daily gain (ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake (RFI) and select 20 animals for the high feed efficient (LRFI) and 20 for the low feed efficient (HRFI) groups. Blood samples were collected on d 56 and at slaughter (80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels. RESULTS: DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness, as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter (P = 0.0049). Gene expression of leptin were greater in LRFI animals (P = 0.0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression. CONCLUSION: These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake. BioMed Central 2017-09-01 /pmc/articles/PMC5580337/ /pubmed/28883916 http://dx.doi.org/10.1186/s40104-017-0203-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Mota, Lúcio Flávio Macedo
Bonafé, Cristina Moreira
Alexandre, Pâmela Almeida
Santana, Miguel Henrique
Novais, Francisco José
Toriyama, Erika
Pires, Aldrin Vieira
da Luz Silva, Saulo
Leme, Paulo Roberto
Ferraz, José Bento Sterman
Fukumasu, Heidge
Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency
title Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency
title_full Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency
title_fullStr Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency
title_full_unstemmed Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency
title_short Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency
title_sort circulating leptin and its muscle gene expression in nellore cattle with divergent feed efficiency
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580337/
https://www.ncbi.nlm.nih.gov/pubmed/28883916
http://dx.doi.org/10.1186/s40104-017-0203-3
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