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Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies
Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are relentlessly progressive neurodegenerative disorders that are likely to represent two ends of a disease spectrum. It is well established that both are characterised pathologically by widespread cortical Lewy body deposition....
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580419/ https://www.ncbi.nlm.nih.gov/pubmed/28928962 http://dx.doi.org/10.12688/f1000research.11725.1 |
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author | Weil, Rimona S. Lashley, Tammaryn L. Bras, Jose Schrag, Anette E. Schott, Jonathan M. |
author_facet | Weil, Rimona S. Lashley, Tammaryn L. Bras, Jose Schrag, Anette E. Schott, Jonathan M. |
author_sort | Weil, Rimona S. |
collection | PubMed |
description | Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are relentlessly progressive neurodegenerative disorders that are likely to represent two ends of a disease spectrum. It is well established that both are characterised pathologically by widespread cortical Lewy body deposition. However, until recently, the pathophysiological mechanisms leading to neuronal damage were not known. It was also not understood why some cells are particularly vulnerable in PDD/DLB, nor why some individuals show more aggressive and rapid dementia than others. Recent studies using animal and cell models as well as human post-mortem analyses have provided important insights into these questions. Here, we review recent developments in the pathophysiology in PDD/DLB. Specifically, we examine the role of pathological proteins other than α-synuclein, consider particular morphological and physiological features that confer vulnerabilities on some neurons rather than others, and finally examine genetic factors that may explain some of the heterogeneity between individuals with PDD/DLB. |
format | Online Article Text |
id | pubmed-5580419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-55804192017-09-18 Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies Weil, Rimona S. Lashley, Tammaryn L. Bras, Jose Schrag, Anette E. Schott, Jonathan M. F1000Res Review Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are relentlessly progressive neurodegenerative disorders that are likely to represent two ends of a disease spectrum. It is well established that both are characterised pathologically by widespread cortical Lewy body deposition. However, until recently, the pathophysiological mechanisms leading to neuronal damage were not known. It was also not understood why some cells are particularly vulnerable in PDD/DLB, nor why some individuals show more aggressive and rapid dementia than others. Recent studies using animal and cell models as well as human post-mortem analyses have provided important insights into these questions. Here, we review recent developments in the pathophysiology in PDD/DLB. Specifically, we examine the role of pathological proteins other than α-synuclein, consider particular morphological and physiological features that confer vulnerabilities on some neurons rather than others, and finally examine genetic factors that may explain some of the heterogeneity between individuals with PDD/DLB. F1000Research 2017-08-30 /pmc/articles/PMC5580419/ /pubmed/28928962 http://dx.doi.org/10.12688/f1000research.11725.1 Text en Copyright: © 2017 Weil RS et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Weil, Rimona S. Lashley, Tammaryn L. Bras, Jose Schrag, Anette E. Schott, Jonathan M. Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies |
title | Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies |
title_full | Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies |
title_fullStr | Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies |
title_full_unstemmed | Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies |
title_short | Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies |
title_sort | current concepts and controversies in the pathogenesis of parkinson’s disease dementia and dementia with lewy bodies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580419/ https://www.ncbi.nlm.nih.gov/pubmed/28928962 http://dx.doi.org/10.12688/f1000research.11725.1 |
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