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Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies

Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are relentlessly progressive neurodegenerative disorders that are likely to represent two ends of a disease spectrum. It is well established that both are characterised pathologically by widespread cortical Lewy body deposition....

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Autores principales: Weil, Rimona S., Lashley, Tammaryn L., Bras, Jose, Schrag, Anette E., Schott, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580419/
https://www.ncbi.nlm.nih.gov/pubmed/28928962
http://dx.doi.org/10.12688/f1000research.11725.1
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author Weil, Rimona S.
Lashley, Tammaryn L.
Bras, Jose
Schrag, Anette E.
Schott, Jonathan M.
author_facet Weil, Rimona S.
Lashley, Tammaryn L.
Bras, Jose
Schrag, Anette E.
Schott, Jonathan M.
author_sort Weil, Rimona S.
collection PubMed
description Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are relentlessly progressive neurodegenerative disorders that are likely to represent two ends of a disease spectrum. It is well established that both are characterised pathologically by widespread cortical Lewy body deposition. However, until recently, the pathophysiological mechanisms leading to neuronal damage were not known. It was also not understood why some cells are particularly vulnerable in PDD/DLB, nor why some individuals show more aggressive and rapid dementia than others. Recent studies using animal and cell models as well as human post-mortem analyses have provided important insights into these questions. Here, we review recent developments in the pathophysiology in PDD/DLB. Specifically, we examine the role of pathological proteins other than α-synuclein, consider particular morphological and physiological features that confer vulnerabilities on some neurons rather than others, and finally examine genetic factors that may explain some of the heterogeneity between individuals with PDD/DLB.
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spelling pubmed-55804192017-09-18 Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies Weil, Rimona S. Lashley, Tammaryn L. Bras, Jose Schrag, Anette E. Schott, Jonathan M. F1000Res Review Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) are relentlessly progressive neurodegenerative disorders that are likely to represent two ends of a disease spectrum. It is well established that both are characterised pathologically by widespread cortical Lewy body deposition. However, until recently, the pathophysiological mechanisms leading to neuronal damage were not known. It was also not understood why some cells are particularly vulnerable in PDD/DLB, nor why some individuals show more aggressive and rapid dementia than others. Recent studies using animal and cell models as well as human post-mortem analyses have provided important insights into these questions. Here, we review recent developments in the pathophysiology in PDD/DLB. Specifically, we examine the role of pathological proteins other than α-synuclein, consider particular morphological and physiological features that confer vulnerabilities on some neurons rather than others, and finally examine genetic factors that may explain some of the heterogeneity between individuals with PDD/DLB. F1000Research 2017-08-30 /pmc/articles/PMC5580419/ /pubmed/28928962 http://dx.doi.org/10.12688/f1000research.11725.1 Text en Copyright: © 2017 Weil RS et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Weil, Rimona S.
Lashley, Tammaryn L.
Bras, Jose
Schrag, Anette E.
Schott, Jonathan M.
Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies
title Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies
title_full Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies
title_fullStr Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies
title_full_unstemmed Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies
title_short Current concepts and controversies in the pathogenesis of Parkinson’s disease dementia and Dementia with Lewy Bodies
title_sort current concepts and controversies in the pathogenesis of parkinson’s disease dementia and dementia with lewy bodies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580419/
https://www.ncbi.nlm.nih.gov/pubmed/28928962
http://dx.doi.org/10.12688/f1000research.11725.1
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