Cargando…

Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes

Under physiological conditions, the function of astrocytes in providing brain metabolic support is compromised under pathophysiological conditions caused by human immunodeficiency virus (HIV) and opioids. Herein, we examined the role of autophagy, a lysosomal degradation pathway important for cellul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodriguez, Myosotys, Lapierre, Jessica, Ojha, Chet Raj, Estrada-Bueno, Hary, Dever, Seth M., Gewirtz, David A., Kashanchi, Fatah, El-Hage, Nazira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580458/ https://www.ncbi.nlm.nih.gov/pubmed/28788100 http://dx.doi.org/10.3390/v9080201

Ejemplares similares

Toll-like receptor 3 regulates Zika virus infection and associated host inflammatory response in primary human astrocytes
por: Ojha, Chet Raj, et al.
Publicado: (2019)

Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications
por: Ojha, Chet Raj, et al.
Publicado: (2017)

Author Correction: Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation
por: Rodriguez, Myosotys, et al.
Publicado: (2018)

Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation
por: Rodriguez, Myosotys, et al.
Publicado: (2017)

Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure
por: Dever, Seth M., et al.
Publicado: (2015)

Mammalian microRNA: an important modulator of host-pathogen interactions in human viral infections
por: Ojha, Chet Raj, et al.
Publicado: (2016)

Complementary Mechanisms Potentially Involved in the Pathology of Zika Virus
por: Ojha, Chet Raj, et al.
Publicado: (2018)

Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy
por: Karuppan, Mohan Kumar Muthu, et al.
Publicado: (2020)

HIV-1 Nef blocks autophagy in human astrocytes
por: Sardo, Luca, et al.
Publicado: (2015)

Autophagy, EVs, and Infections: A Perfect Question for a Perfect Time
por: Pleet, Michelle L., et al.
Publicado: (2018)

Inhibition of human immunodeficiency virus type-1 by cdk inhibitors
por: Guendel, Irene, et al.
Publicado: (2010)

Intracytoplasmic maturation of the human immunodeficiency virus type 1 reverse transcription complexes determines their capacity to integrate into chromatin
por: Iordanskiy, Sergey, et al.
Publicado: (2006)

Implication of the Autophagy-Related Protein Beclin1 in the Regulation of EcoHIV Replication and Inflammatory Responses
por: Rodriguez, Myosotys, et al.
Publicado: (2023)

The Impact of CRISPR-Cas9 on Age-related Disorders: From Pathology to Therapy
por: Caobi, Allen, et al.
Publicado: (2020)

Morphine Exacerbates HIV-1 Tat-Induced Cytokine Production in Astrocytes through Convergent Effects on [Ca(2+)](i), NF-κB Trafficking and Transcription
por: El-Hage, Nazira, et al.
Publicado: (2008)

Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Nervous System: Implications of COVID-19 in Neurodegeneration
por: Rodriguez, Myosotys, et al.
Publicado: (2020)

Retroviral infection of human neurospheres and use of stem Cell EVs to repair cellular damage
por: Branscome, Heather, et al.
Publicado: (2022)

SERPIN-Derived Small Peptide (SP16) as a Potential Therapeutic Agent against HIV-Induced Inflammatory Molecules and Viral Replication in Cells of the Central Nervous System
por: Soler, Yemmy, et al.
Publicado: (2023)

Extracellular Vesicles Released by Genetically Modified Macrophages Activate Autophagy and Produce Potent Neuroprotection in Mouse Model of Lysosomal Storage Disorder, Batten Disease
por: El-Hage, Nazira, et al.
Publicado: (2023)

Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair
por: Branscome, Heather, et al.
Publicado: (2020)

Morphine Enhances HIV-1(SF162)-Mediated Neuron Death and Delays Recovery of Injured Neurites
por: Masvekar, Ruturaj R., et al.
Publicado: (2014)

Autophagy in Human T-Cell Leukemia Virus Type 1 (HTLV-1) Induced Leukemia
por: Ducasa, Nicolás, et al.
Publicado: (2021)

Targeting Beclin1 as an Adjunctive Therapy against HIV Using Mannosylated Polyethylenimine Nanoparticles
por: Rodriguez, Myosotys, et al.
Publicado: (2021)

The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly
por: Zapata, Juan C., et al.
Publicado: (2017)

Pulmonary Kaposi's sarcoma as the initial presentation of human immunodeficiency virus infection
por: Imran, Tasnim F., et al.
Publicado: (2014)

HIV-1 gp120 and morphine induced oxidative stress: role in cell cycle regulation
por: Samikkannu, Thangavel, et al.
Publicado: (2015)

In human astrocytes neurotropic flaviviruses increase autophagy, yet their replication is autophagy-independent
por: Tavčar Verdev, Petra, et al.
Publicado: (2022)

Modeling the Effects of Morphine on Simian Immunodeficiency Virus Dynamics
por: Vaidya, Naveen K., et al.
Publicado: (2016)

The utilization of humanized mouse models for the study of human retroviral infections
por: Van Duyne, Rachel, et al.
Publicado: (2009)

The utilization of humanized mouse models for the study of inhibitors in HTLV-1 infection
por: Van Duyne, Rachel, et al.
Publicado: (2011)

Astrocytes & Astrocyte derived Extracellular Vesicles in Morphine Induced Amyloidopathy: Implications for Cognitive Deficits in Opiate Abusers
por: Sil, Susmita, et al.
Publicado: (2021)

HIV Increases the Inhibitory Impact of Morphine and Antiretrovirals on Autophagy in Primary Human Macrophages: Contributions to Neuropathogenesis
por: Barbaro, John M., et al.
Publicado: (2021)

The versatile role of exosomes in human retroviral infections: from immunopathogenesis to clinical application
por: Rezaie, Jafar, et al.
Publicado: (2021)

Atypical Tinea Corporis Revealing a Human Immunodeficiency Virus Infection
por: Brown, Joelle, et al.
Publicado: (2020)

Tat gets the "green" light on transcription initiation
por: Brady, John, et al.
Publicado: (2005)

New and novel intrinsic host repressive factors against HIV-1: PAF1 complex, HERC5 and others
por: Tyagi, Mudit, et al.
Publicado: (2012)

Human immunodeficiency virus type 1 efficiently binds to human fetal astrocytes and induces neuroinflammatory responses independent of infection
por: Li, Jinliang, et al.
Publicado: (2007)

Human T-Lymphotropic Virus Type 1 transcription and chromatin-remodeling complexes
por: Easley, Rebecca, et al.
Publicado: (2011)

Experiments on the Operation of Morphine in the Human Body
Publicado: (1829)

Distinct Profiles of Anxiety and Dysphoria during Spontaneous Withdrawal from Acute Morphine Exposure
por: Rothwell, Patrick E., et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_j4puvi2mhrbbav4ebnodocgigt