Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis

Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral outbreaks, new treatments are urgently needed. Developing new virus control modalities requires bet...

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Detalles Bibliográficos
Autores principales: Shim, Jung Min, Kim, Jinhee, Tenson, Tanel, Min, Ji-Young, Kainov, Denis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580480/
https://www.ncbi.nlm.nih.gov/pubmed/28805681
http://dx.doi.org/10.3390/v9080223
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author Shim, Jung Min
Kim, Jinhee
Tenson, Tanel
Min, Ji-Young
Kainov, Denis E.
author_facet Shim, Jung Min
Kim, Jinhee
Tenson, Tanel
Min, Ji-Young
Kainov, Denis E.
author_sort Shim, Jung Min
collection PubMed
description Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral outbreaks, new treatments are urgently needed. Developing new virus control modalities requires better understanding of virus-host interactions. Here, we describe how IAV infection triggers cellular apoptosis and how this process can be exploited towards the development of new therapeutics, which might be more effective than the currently available anti-influenza drugs.
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spelling pubmed-55804802017-09-06 Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis Shim, Jung Min Kim, Jinhee Tenson, Tanel Min, Ji-Young Kainov, Denis E. Viruses Review Human influenza A viruses (IAVs) cause global pandemics and epidemics, which remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral outbreaks, new treatments are urgently needed. Developing new virus control modalities requires better understanding of virus-host interactions. Here, we describe how IAV infection triggers cellular apoptosis and how this process can be exploited towards the development of new therapeutics, which might be more effective than the currently available anti-influenza drugs. MDPI 2017-08-12 /pmc/articles/PMC5580480/ /pubmed/28805681 http://dx.doi.org/10.3390/v9080223 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shim, Jung Min
Kim, Jinhee
Tenson, Tanel
Min, Ji-Young
Kainov, Denis E.
Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis
title Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis
title_full Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis
title_fullStr Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis
title_full_unstemmed Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis
title_short Influenza Virus Infection, Interferon Response, Viral Counter-Response, and Apoptosis
title_sort influenza virus infection, interferon response, viral counter-response, and apoptosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580480/
https://www.ncbi.nlm.nih.gov/pubmed/28805681
http://dx.doi.org/10.3390/v9080223
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AT tensontanel influenzavirusinfectioninterferonresponseviralcounterresponseandapoptosis
AT minjiyoung influenzavirusinfectioninterferonresponseviralcounterresponseandapoptosis
AT kainovdenise influenzavirusinfectioninterferonresponseviralcounterresponseandapoptosis

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