Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity

Lung adenocarcinoma accounts for ∼40% of lung cancers, the leading cause of cancer-related death worldwide, and current therapies provide only limited survival benefit. Approximately half of lung adenocarcinomas harbor mutations in TP53 (p53), making these mutants appealing targets for lung cancer t...

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Detalles Bibliográficos
Autores principales: Turrell, Frances K., Kerr, Emma M., Gao, Meiling, Thorpe, Hannah, Doherty, Gary J., Cridge, Jake, Shorthouse, David, Speed, Alyson, Samarajiwa, Shamith, Hall, Benjamin A., Griffiths, Meryl, Martins, Carla P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580655/
https://www.ncbi.nlm.nih.gov/pubmed/28790158
http://dx.doi.org/10.1101/gad.298463.117

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