Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors

Aflatoxin B1 (AFB1) is a mutagen and IARC (International Agency for Research on Cancer) Group 1 carcinogen that causes hepatocellular carcinoma (HCC). Here, we present the first whole-genome data on the mutational signatures of AFB1 exposure from a total of >40,000 mutations in four experimental...

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Detalles Bibliográficos
Autores principales: Huang, Mi Ni, Yu, Willie, Teoh, Wei Wei, Ardin, Maude, Jusakul, Apinya, Ng, Alvin Wei Tian, Boot, Arnoud, Abedi-Ardekani, Behnoush, Villar, Stephanie, Myint, Swe Swe, Othman, Rashidah, Poon, Song Ling, Heguy, Adriana, Olivier, Magali, Hollstein, Monica, Tan, Patrick, Teh, Bin Tean, Sabapathy, Kanaga, Zavadil, Jiri, Rozen, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580708/
https://www.ncbi.nlm.nih.gov/pubmed/28739859
http://dx.doi.org/10.1101/gr.220038.116

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