Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug target

To understand disease mechanisms, a large-scale analysis of human–yeast genetic interactions was performed. Of 1305 human disease genes assayed, 20 genes exhibited strong toxicity in yeast. Human–yeast genetic interactions were identified by en masse transformation of the human disease genes into a...

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Detalles Bibliográficos
Autores principales: Jo, Myungjin, Chung, Ah Young, Yachie, Nozomu, Seo, Minchul, Jeon, Hyejin, Nam, Youngpyo, Seo, Yeojin, Kim, Eunmi, Zhong, Quan, Vidal, Marc, Park, Hae Chul, Roth, Frederick P., Suk, Kyoungho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580709/
https://www.ncbi.nlm.nih.gov/pubmed/28596290
http://dx.doi.org/10.1101/gr.211649.116

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