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Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia

BACKGROUND: Hematological changes can drive damage of endothelial cells, which potentially lead to an early endothelial dysfunction in patients with sickle cell anemia (SCA). An association may exist between endothelial dysfunction and several clinical manifestations of SCA. The present study aims t...

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Autores principales: Teixeira, Rozana Santos, Terse-Ramos, Regina, Ferreira, Tatiane Anunciação, Machado, Vinícius Ramos, Perdiz, Marya Izadora, Lyra, Isa Menezes, Nascimento, Valma Lopes, Boa-Sorte, Ney, Andrade, Bruno B., Ladeia, Ana Marice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580915/
https://www.ncbi.nlm.nih.gov/pubmed/28863145
http://dx.doi.org/10.1371/journal.pone.0184076
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author Teixeira, Rozana Santos
Terse-Ramos, Regina
Ferreira, Tatiane Anunciação
Machado, Vinícius Ramos
Perdiz, Marya Izadora
Lyra, Isa Menezes
Nascimento, Valma Lopes
Boa-Sorte, Ney
Andrade, Bruno B.
Ladeia, Ana Marice
author_facet Teixeira, Rozana Santos
Terse-Ramos, Regina
Ferreira, Tatiane Anunciação
Machado, Vinícius Ramos
Perdiz, Marya Izadora
Lyra, Isa Menezes
Nascimento, Valma Lopes
Boa-Sorte, Ney
Andrade, Bruno B.
Ladeia, Ana Marice
author_sort Teixeira, Rozana Santos
collection PubMed
description BACKGROUND: Hematological changes can drive damage of endothelial cells, which potentially lead to an early endothelial dysfunction in patients with sickle cell anemia (SCA). An association may exist between endothelial dysfunction and several clinical manifestations of SCA. The present study aims to evaluate the links between changes in endothelial function and clinical and laboratory parameters in children and adolescents with SCA. METHODS: This study included 40 children and adolescents with stable SCA as well as 25 healthy children; aged 6–18 years. All study subjects were evaluated for endothelial function using Doppler ultrasonography. In addition, a number of laboratory assays were performed, including reticulocyte and leukocyte counts as well as measurement of circulating levels of total bilirubin, C-reactive protein (CRP), glucose, lipoproteins and peripheral oxyhemoglobin saturation. These parameters were also compared between SCA patients who were undertaking hydroxyurea (HU) and those who were not. RESULTS: Flow-mediated vasodilation (FMD) values were found to be reduced in SCA patients compared with those detected in healthy controls. SCA individuals with lower FMD values exhibited higher number of hospital admissions due to vaso-occlusive events. Additional analyses revealed that patients who had decreased FMD values exhibited higher odds of acute chest syndrome (ACS) episodes. A preliminary analysis with limited number of individuals failed to demonstrate significant differences in FMD values between SCA individuals who were treated with HU and those who were not. CONCLUSIONS: Children and adolescents with SCA exhibit impaired endothelial function. Reductions in FMD values are associated with ACS. These findings underline the potential use of FMD as screening strategy of SCA patients with severe prognosis at early stages.
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spelling pubmed-55809152017-09-15 Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia Teixeira, Rozana Santos Terse-Ramos, Regina Ferreira, Tatiane Anunciação Machado, Vinícius Ramos Perdiz, Marya Izadora Lyra, Isa Menezes Nascimento, Valma Lopes Boa-Sorte, Ney Andrade, Bruno B. Ladeia, Ana Marice PLoS One Research Article BACKGROUND: Hematological changes can drive damage of endothelial cells, which potentially lead to an early endothelial dysfunction in patients with sickle cell anemia (SCA). An association may exist between endothelial dysfunction and several clinical manifestations of SCA. The present study aims to evaluate the links between changes in endothelial function and clinical and laboratory parameters in children and adolescents with SCA. METHODS: This study included 40 children and adolescents with stable SCA as well as 25 healthy children; aged 6–18 years. All study subjects were evaluated for endothelial function using Doppler ultrasonography. In addition, a number of laboratory assays were performed, including reticulocyte and leukocyte counts as well as measurement of circulating levels of total bilirubin, C-reactive protein (CRP), glucose, lipoproteins and peripheral oxyhemoglobin saturation. These parameters were also compared between SCA patients who were undertaking hydroxyurea (HU) and those who were not. RESULTS: Flow-mediated vasodilation (FMD) values were found to be reduced in SCA patients compared with those detected in healthy controls. SCA individuals with lower FMD values exhibited higher number of hospital admissions due to vaso-occlusive events. Additional analyses revealed that patients who had decreased FMD values exhibited higher odds of acute chest syndrome (ACS) episodes. A preliminary analysis with limited number of individuals failed to demonstrate significant differences in FMD values between SCA individuals who were treated with HU and those who were not. CONCLUSIONS: Children and adolescents with SCA exhibit impaired endothelial function. Reductions in FMD values are associated with ACS. These findings underline the potential use of FMD as screening strategy of SCA patients with severe prognosis at early stages. Public Library of Science 2017-09-01 /pmc/articles/PMC5580915/ /pubmed/28863145 http://dx.doi.org/10.1371/journal.pone.0184076 Text en © 2017 Teixeira et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Teixeira, Rozana Santos
Terse-Ramos, Regina
Ferreira, Tatiane Anunciação
Machado, Vinícius Ramos
Perdiz, Marya Izadora
Lyra, Isa Menezes
Nascimento, Valma Lopes
Boa-Sorte, Ney
Andrade, Bruno B.
Ladeia, Ana Marice
Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia
title Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia
title_full Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia
title_fullStr Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia
title_full_unstemmed Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia
title_short Associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia
title_sort associations between endothelial dysfunction and clinical and laboratory parameters in children and adolescents with sickle cell anemia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580915/
https://www.ncbi.nlm.nih.gov/pubmed/28863145
http://dx.doi.org/10.1371/journal.pone.0184076
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