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The mTOR inhibitor everolimus in combination with azacitidine in patients with relapsed/refractory acute myeloid leukemia: a phase Ib/II study
Therapeutic options are limited in relapsed/refractory acute myeloid leukemia (AML). We evaluated the maximum tolerated dose (MTD) and preliminary efficacy of mammalian target of rapamycin (mTOR) inhibitor, everolimus (days 5–21) in combination with azacitidine 75 mg/m(2) subcutaneously (days 1–5 an...
Autores principales: | Tan, Peter, Tiong, Ing Soo, Fleming, Shaun, Pomilio, Giovanna, Cummings, Nik, Droogleever, Mark, McManus, Julie, Schwarer, Anthony, Catalano, John, Patil, Sushrut, Avery, Sharon, Spencer, Andrew, Wei, Andrew |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581027/ https://www.ncbi.nlm.nih.gov/pubmed/28881728 http://dx.doi.org/10.18632/oncotarget.13699 |
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