Detection of BRAF, NRAS, KIT, GNAQ, GNA11 and MAP2K1/2 mutations in Russian melanoma patients using LNA PCR clamp and biochip analysis

Target inhibitors are used for melanoma treatment, and their effectiveness depends on the tumor genotype. We developed a diagnostic biochip for the detection of 39 clinically relevant somatic mutations in the BRAF, NRAS, KIT, GNAQ, GNA11, MAP2K1 and MAP2K2 genes. We used multiplex locked nucleic aci...

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Detalles Bibliográficos
Autores principales: Emelyanova, Marina, Ghukasyan, Lilit, Abramov, Ivan, Ryabaya, Oxana, Stepanova, Evgenia, Kudryavtseva, Anna, Sadritdinova, Asiya, Dzhumakova, Cholpon, Belysheva, Tatiana, Surzhikov, Sergey, Lyubchenko, Lyudmila, Zasedatelev, Alexander, Nasedkina, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581030/
https://www.ncbi.nlm.nih.gov/pubmed/28881731
http://dx.doi.org/10.18632/oncotarget.17014

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