Targeting aldehyde dehydrogenase activity in head and neck squamous cell carcinoma with a novel small molecule inhibitor

Chemoresistant cancer cells express high levels of aldehyde dehydrogenases (ALDHs), particularly in head and neck squamous cell carcinoma (HNSCC). The ALDH family of enzymes detoxify both exogenous and endogenous aldehydes. Since many chemotherapeutic agents, such as cisplatin, result in the generat...

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Detalles Bibliográficos
Autores principales: Kim, Jeewon, Shin, June Ho, Chen, Che-Hong, Cruz, Leslie, Farnebo, Lovisa, Yang, Jieying, Borges, Paula, Kang, Gugene, Mochly-Rosen, Daria, Sunwoo, John B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581033/
https://www.ncbi.nlm.nih.gov/pubmed/28881734
http://dx.doi.org/10.18632/oncotarget.17017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581033/
https://www.ncbi.nlm.nih.gov/pubmed/28881734
http://dx.doi.org/10.18632/oncotarget.17017

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