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Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction
Several studies addressed the association between Intercellular adhesion molecule 1 (ICAM-1) rs5498 polymorphism and Myocardial Infarction (MI) risk. However, they addressed conflicting findings. Therefore, the aim of this study was to explore whether ICAM-1 gene rs5498 polymorphism plays an importa...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581053/ https://www.ncbi.nlm.nih.gov/pubmed/28881754 http://dx.doi.org/10.18632/oncotarget.17529 |
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author | Hu, Pengfei Dai, Tao Yu, Weiwei Luo, Ying Huang, Shuwei |
author_facet | Hu, Pengfei Dai, Tao Yu, Weiwei Luo, Ying Huang, Shuwei |
author_sort | Hu, Pengfei |
collection | PubMed |
description | Several studies addressed the association between Intercellular adhesion molecule 1 (ICAM-1) rs5498 polymorphism and Myocardial Infarction (MI) risk. However, they addressed conflicting findings. Therefore, the aim of this study was to explore whether ICAM-1 gene rs5498 polymorphism plays an important role in modifying the risk of MI. A meta-analysis was conducted on the association between ICAM-1 rs5498 polymorphism and MI. 12 eligible studies involving 1,696 cases and 3,039 controls were included in the meta-analysis. Meta-analysis revealed that ICAM-1 rs5498 polymorphism showed a strongly positive correlation with MI and could be viewed as a protective factor for MI. Furthermore, subgroup analysis according to ethnicity indicated that ICAM-1 rs5498 polymorphism decreased the risk of MI among Caucasian and Asian populations. In conclusion, ICAM-1 rs5498 polymorphism was associated with the decreased risk of MI. Larger sample size studies with more diverse ethnic populations are needed to confirm these findings. |
format | Online Article Text |
id | pubmed-5581053 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55810532017-09-06 Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction Hu, Pengfei Dai, Tao Yu, Weiwei Luo, Ying Huang, Shuwei Oncotarget Research Paper Several studies addressed the association between Intercellular adhesion molecule 1 (ICAM-1) rs5498 polymorphism and Myocardial Infarction (MI) risk. However, they addressed conflicting findings. Therefore, the aim of this study was to explore whether ICAM-1 gene rs5498 polymorphism plays an important role in modifying the risk of MI. A meta-analysis was conducted on the association between ICAM-1 rs5498 polymorphism and MI. 12 eligible studies involving 1,696 cases and 3,039 controls were included in the meta-analysis. Meta-analysis revealed that ICAM-1 rs5498 polymorphism showed a strongly positive correlation with MI and could be viewed as a protective factor for MI. Furthermore, subgroup analysis according to ethnicity indicated that ICAM-1 rs5498 polymorphism decreased the risk of MI among Caucasian and Asian populations. In conclusion, ICAM-1 rs5498 polymorphism was associated with the decreased risk of MI. Larger sample size studies with more diverse ethnic populations are needed to confirm these findings. Impact Journals LLC 2017-04-29 /pmc/articles/PMC5581053/ /pubmed/28881754 http://dx.doi.org/10.18632/oncotarget.17529 Text en Copyright: © 2017 Hu et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Hu, Pengfei Dai, Tao Yu, Weiwei Luo, Ying Huang, Shuwei Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction |
title | Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction |
title_full | Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction |
title_fullStr | Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction |
title_full_unstemmed | Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction |
title_short | Intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction |
title_sort | intercellular adhesion molecule 1 rs5498 polymorphism is associated with the risk of myocardial infarction |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581053/ https://www.ncbi.nlm.nih.gov/pubmed/28881754 http://dx.doi.org/10.18632/oncotarget.17529 |
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