Transgenic overexpression of NanogP8 in the mouse prostate is insufficient to initiate tumorigenesis but weakly promotes tumor development in the Hi-Myc mouse model

This project was undertaken to address a critical cancer biology question: Is overexpression of the pluripotency molecule Nanog sufficient to initiate tumor development in a somatic tissue? Nanog1 is critical for the self-renewal and pluripotency of ES cells, and its retrotransposed homolog, NanogP8...

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Detalles Bibliográficos
Autores principales: Liu, Bigang, Gong, Shuai, Li, Qiuhui, Chen, Xin, Moore, John, Suraneni, Mahipal V., Badeaux, Mark D., Jeter, Collene R., Shen, Jianjun, Mehmood, Rashid, Fan, Qingxia, Tang, Dean G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581066/
https://www.ncbi.nlm.nih.gov/pubmed/28881767
http://dx.doi.org/10.18632/oncotarget.17186

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